The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members Journal Article
| Authors: | Farazi, T. A.; Juranek, S. A.; Tuschl, T. |
| Article Title: | The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members |
| Abstract: | Several distinct classes of small RNAs, some newly identified, have been discovered to play important regulatory roles in diverse cellular processes. These classes include siRNAs, miRNAs, rasiRNAs and piRNAs. Each class binds to distinct members of the Argonaute/Piwi protein family to form ribonucleoprotein complexes that recognize partially, or nearly perfect, complementary nucleic acid targets, and that mediate a variety of regulatory processes, including transcriptional and post-transcriptional gene silencing. Based on the known relationship of Argonaute/Piwi proteins with distinct classes of small RNAs, we can now predict how many new classes of small RNAs or silencing processes remain to be discovered. |
| Keywords: | protein expression; gene sequence; review; nonhuman; protein function; proteins; microrna; models, biological; small interfering rna; rna, small interfering; genetic association; rna interference; rna binding protein; rna; rna-binding proteins; gene repression; gene control; models, molecular; protein structure, tertiary; drosophila melanogaster; protein structure; micrornas; rna helicase; argonaute protein; genetic conservation; transposon; biogenesis; ribonuclease iii; complementary rna; phylogeny; rna polymerase; piwi protein; rna methyltransferase; rna methylation; dna library; posttranscriptional gene silencing |
| Journal Title: | Development |
| Volume: | 135 |
| Issue: | 7 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2008-04-01 |
| Start Page: | 1201 |
| End Page: | 1214 |
| Language: | English |
| DOI: | 10.1242/dev.005629 |
| PUBMED: | 18287206 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 119" - "Export Date: 17 November 2011" - "CODEN: DEVPE" - "Source: Scopus" |
