Efficacy of insulin-like growth factor binding protein 3 in predicting the growth hormone response to provocative testing in children treated with cranial irradiation Journal Article
| Authors: | Sklar, C.; Sarafoglou, K.; Whittam, E. |
| Article Title: | Efficacy of insulin-like growth factor binding protein 3 in predicting the growth hormone response to provocative testing in children treated with cranial irradiation |
| Abstract: | Recent data suggest that the plasma concentration of insulin-like growth factor binding protein 3 (IGFBP-3) is useful as a screening test for growth hormone (GH) deficiency. In this study, we measured by radioimmunoassay the levels of IGFBP-3 in a group of 20 subjects (12 males) of 5 years and 7 months to 16 years of age undergoing standard GH testing following cranial irradiation. The patients had received 1800 to > 6000 cGy of radiation to the hypothalamic-pituitary region, a median of 2.7 years (range 2-7 years) prior to testing. The IGFBP-3 concentrations were discordant with the results of GH testing 60% (12/20) of the time. Although IGFBP-3 levels were below the mean for age in 14 of 15 GH-deficient (peak GH < 10 μg/l) patients, only three of 15 GH-deficient patients had IGFBP-3 concentrations that fell below age-adjusted norms. In contrast, the IGFBP-3 levels were within the normal range in all five patients with normal GH responses. The low sensitivity (20%) of IGFBP-3 in predicting the subjects with abnormal responses was not improved by adjusting the values for bone age or stage of puberty. We conclude that a single plasma determination of IGFBP-3 is not a useful screening test for GH deficiency among patients previously treated with cranial irradiation. |
| Keywords: | adolescent; child; clinical article; controlled study; child, preschool; brain neoplasms; growth hormone; growth hormone deficiency; skull irradiation; carrier proteins; forecasting; body height; insulin-like growth factor i; somatomedin binding protein; clonidine; levodopa; osmolar concentration; human; male; female; priority journal; article; insulin-like growth-factor-binding proteins |
| Journal Title: | Acta Endocrinologica |
| Volume: | 129 |
| Issue: | 6 |
| ISSN: | 0001-5598 |
| Publisher: | BioScientifica Ltd. |
| Date Published: | 1993-12-01 |
| Start Page: | 511 |
| End Page: | 515 |
| Language: | English |
| PUBMED: | 7509100 |
| PROVIDER: | scopus |
| DOI: | 10.1530/acta.0.1290511 |
| DOI/URL: | |
| Notes: | Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work