Focal treatment of prostate cancer with vascular-targeted photodynamic therapy Journal Article
| Authors: | Eggener, S. E.; Coleman, J. A. |
| Article Title: | Focal treatment of prostate cancer with vascular-targeted photodynamic therapy |
| Abstract: | Epidemiologic and pathologic features of prostate cancer have given rise to an interest in focal treatment for carefully selected patients. Prostate cancer remains highly prevalent, particularly in the U.S. and Europe. As screening programs have become more aggressive and widespread, a substantial proportion of men diagnosed with localized prostate cancer have disease characteristics associated with a low risk of progression. Treatments such as radical prostatectomy and radiation therapy can lead to durable recurrence-free survival in most patients, but carry variable risks of bowel, urinary, and sexual side effects. Few men and few urologists are comfortable leaving a potentially curable prostate cancer untreated. Focal therapy offers an attractive alternative for the patient faced with a choice between aggressive local intervention (radiation or surgery) and watchful waiting. Contemporary diagnostic biopsy strategies and imaging tools, and the development of predictive statistical models (nomograms), have led to improvements in tumor characterization and risk stratification, making focal therapy a viable treatment option for specific men. This article reviews the rationale and indications for focal therapy and highlights vascular-targeted photodynamic therapy (PDT) as one of many promising focal therapy techniques. ©2008 with author. Published by TheScientificWorld. |
| Keywords: | treatment response; clinical trial; drug tolerability; review; drug safety; nonhuman; side effect; nuclear magnetic resonance imaging; magnetic resonance imaging; cancer diagnosis; prostate specific antigen; animals; morbidity; prevalence; cancer mortality; drug dose escalation; prostate cancer; prostatic neoplasms; hypotension; dog; prostate biopsy; photodynamic therapy; photochemotherapy; swine; photofrin; photosensitizing agent; progesterone; focal therapy; verteporfin; urinary dysfunction; phototoxicity; photoallergy; etiopurpurin; palladium bacteriopheophorbide; temoporfin; bacteriochlorophylls |
| Journal Title: | The Scientific World Journal |
| Volume: | 8 |
| ISSN: | 1537-744X |
| Publisher: | The Scientific World Journal |
| Date Published: | 2008-10-03 |
| Start Page: | 963 |
| End Page: | 973 |
| Language: | English |
| DOI: | 10.1100/tsw.2008.127 |
| PUBMED: | 18836668 |
| PROVIDER: | scopus |
| PMCID: | PMC2692990 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "Source: Scopus" |
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