An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors Journal Article
| Authors: | Eaby, B.; Culkin, A.; Lacouture, M. E. |
| Article Title: | An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors |
| Abstract: | The use of human epidermal growth factor receptor (HER1/EGFR) inhibitors, such as erlotinib, cetuximab, and panitumumab, often is accompanied by the development of a characteristic spectrum of skin toxicities. Although these toxicities rarely are life threatening, they can cause physical and emotional distress for patients and caregivers. As a result, practitioners often withdraw the drug, potentially depriving patients of a benefcial clinical outcome. These reactions do not necessarily require any alteration in HER1/EGFR-inhibitor treatment and often are best addressed through symptomatic treatment. Although the evidence for using such therapies is limited, an interdisciplinary HER1/EGFR-inhibitor dermatologic toxicity forum was held in October 2006 to discuss the underlying mechanisms of these toxicities and evaluate commonly used therapeutic interventions. The result was a proposal for a simple, three-tiered grading system for skin toxicities related to HER1/EGFR inhibitors to be used in therapeutic decision making and as a framework for building a stepwise approach to intervention. |
| Keywords: | erlotinib; patient selection; antineoplastic agents; conference paper; antineoplastic agent; evidence based medicine; evidence-based medicine; quality control; drug eruption; protein kinase inhibitor; incidence; epidermal growth factor receptor; practice guideline; receptor, epidermal growth factor; algorithms; cetuximab; monoclonal antibody; panitumumab; protein kinase inhibitors; hospitalization; antibodies, monoclonal; drug antagonism; severity of illness index; algorithm; practice guidelines as topic; benchmarking; consensus development; quinazolines; decision trees; quinazoline derivative; drug eruptions; decision tree |
| Journal Title: | Clinical Journal of Oncology Nursing |
| Volume: | 12 |
| Issue: | 2 |
| ISSN: | 1092-1095 |
| Publisher: | Oncology Nursing Society (ONS) |
| Date Published: | 2008-01-01 |
| Start Page: | 283 |
| End Page: | 290 |
| Language: | English |
| DOI: | 10.1188/08.cjon.283-290 |
| PUBMED: | 18390464 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 17 November 2011" - "Source: Scopus" |
