Biodistribution and radiation dose estimates for (68)Ga-DOTA-JR11 in patients with metastatic neuroendocrine tumors Journal Article

Authors: Krebs, S.; Pandit-Taskar, N.; Reidy, D.; Beattie, B. J.; Lyashchenko, S. K.; Lewis, J. S.; Bodei, L.; Weber, W. A.; O'Donoghue, J. A.
Article Title: Biodistribution and radiation dose estimates for (68)Ga-DOTA-JR11 in patients with metastatic neuroendocrine tumors
Abstract: Purpose: Somatostatin receptor antagonists have shown promise for imaging neuroendocrine tumors (NETs) in preclinical studies, but clinical data is still very limited. In this study, we assess the feasibility of using the novel somatostatin antagonist 68 Ga-DOTA-JR11 for PET imaging of NETs. Methods: Twenty patients with advanced NETs underwent whole-body PET/CT imaging 60 min after injection of 169 MBq (median) 68 Ga-DOTA-JR11 as part of a prospective study. Volumes of interest were drawn around up to four 68 Ga-DOTA-JR11-avid lesions per patient (with uptake greater than liver) and standardized uptake values were estimated. Additionally, target-to-normal tissue ratios were calculated. A subset of six patients had additional imaging (25-min dynamic scan of the upper abdomen including, at least partly, cardiac left ventricle, liver, spleen, and kidney, and a whole-body PET/CT scan at 30 min post-injection) to determine the time course of tracer distribution and facilitate radiation dose estimates. Absorbed doses were calculated using OLINDA/EXM 1.0. Results: In contrast to the known biodistribution of somatostatin receptor agonists, little or no uptake above background was seen in the pituitary gland, spleen, adrenals, and uninvolved liver; e.g., median spleen SUV mean 1.4 (range: 0.7–1.8), liver SUV mean 1.1 (0.7–1.9). A total of 42 tumor lesions were analyzed with median SUV max 13.0 (range: 2.9–94), TNR blood 9.3 (1.8–87), TNR spleen 4.9 (1.9–48), TNR kidney 2.2 (0.52–28), and TNR liver 10.5 (2.3–107). Tumor uptake reached plateau levels by 20-30 min post-injection. The highest absorbed dose estimates (mGy/MBq) to normal tissues were: urinary bladder wall (0.30; SD 0.06) and kidneys (0.050; SD 0.013). The effective dose (ICRP 103) was 0.022 (SD 0.003) mSv/MBq. Conclusions: 68 Ga-DOTA-JR11 demonstrated rapid tumor uptake, high tumor/background ratios, and rapid clearance from blood. The low liver background is advantageous and may facilitate detection of liver metastases. Dosimetric data compare favorably with published data for 68 Ga-DOTATATE and 68 Ga-DOTATOC. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords: pet/ct; neuroendocrine tumors; jr11; somatostatin receptor antagonists
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 46
Issue: 3
ISSN: 1619-7070
Publisher: Springer  
Date Published: 2019-03-01
Start Page: 677
End Page: 685
Language: English
DOI: 10.1007/s00259-018-4193-y
PUBMED: 30374529
PROVIDER: scopus
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Diane Lauren Reidy
    146 Reidy
  2. Jason S Lewis
    242 Lewis
  3. Bradley Beattie
    106 Beattie
  4. Wolfgang Andreas Weber
    147 Weber
  5. Simone Susanne Krebs
    12 Krebs
  6. Lisa   Bodei
    61 Bodei