Temporal changes in MRI appearance of the prostate after focal ablation Journal Article

Authors: Hötker, A. M.; Meier, A.; Mazaheri, Y.; Zheng, J.; Capanu, M.; Chaim, J.; Sosa, R.; Coleman, J.; Hricak, H.; Akin, O.
Article Title: Temporal changes in MRI appearance of the prostate after focal ablation
Abstract: Purpose: The purpose of our study was to retrospectively evaluate and categorize temporal changes in MRI appearances of the prostate in patients who underwent focal therapy with MRI follow-up. Methods: The Institutional Review Board approved this retrospective study and waived the requirement for informed consent. Thirty-seven patients (median age 61; 48–70 years) with low-to-intermediate-risk, clinically organ-confined prostate cancer underwent focal ablation therapy from 2009 to 2014. Two radiologists reviewed post-treatment MRIs (n = 76) and categorized imaging features blinded to the time interval between the focal therapy and the follow-up MRI. Inter-reader agreement was assessed (kappa) and generalized linear regression was used to examine associations between an imaging feature being present/absent and days between ablation and MRI. Results: Inter-reader agreement on MRI features ranged from fair to substantial. Edema was found present at earlier times after ablation (median 16–25 days compared to MRIs without edema, median 252–514 days), as was rim enhancement of the ablation zone (18–22.5 days vs. 409–593 days), a hypointense rim around the ablation zone on T2-weighted images (53-57.5 days vs. 279–409 days) and the presence of an appreciable ablation cavity (48.5–60 days vs. 613–798 days, all p < 0.05). Enhancement of the ablation zone/scar (553–731 days vs. 61.5–162 days) and the formation of a T2-hypointense scar were found to be present on later MRI scans (514–553 days vs. 29–32 days, one reader). Conclusions: The MRI appearance of the prostate after focal ablation changes substantially over time. Identification of temporal patterns in the appearance of imaging features should help reduce image interpretation variability and errors when assessing post-therapeutic scans. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: magnetic resonance imaging; recurrence; prostate cancer; electroporation; cryosurgery
Journal Title: Abdominal Radiology
Volume: 44
Issue: 1
ISSN: 2366-004X
Publisher: Springer  
Date Published: 2019-01-01
Start Page: 272
End Page: 278
Language: English
DOI: 10.1007/s00261-018-1715-9
PUBMED: 30069583
PROVIDER: scopus
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Jonathan Coleman
    184 Coleman
  2. Joshua Chaim
    17 Chaim
  3. Junting Zheng
    130 Zheng
  4. Marinela Capanu
    206 Capanu
  5. Hedvig Hricak
    330 Hricak
  6. Oguz Akin
    177 Akin
  7. Andreas Markus Hoetker
    21 Hoetker
  8. Ramon Elias Sosa
    16 Sosa
  9. Andreas Alexander Meier
    4 Meier