Trastuzumab gold-conjugates: Synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines Journal Article


Authors: Curado, N.; Dewaele-Le Roi, G.; Poty, S.; Lewis, J. S.; Contel, M.
Article Title: Trastuzumab gold-conjugates: Synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines
Abstract: We describe the preparation of gold(i)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab-gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab. © 2019 The Royal Society of Chemistry.
Journal Title: Chemical Communications
Volume: 55
Issue: 10
ISSN: 1359-7345
Publisher: Royal Society of Chemistry  
Date Published: 2019-02-04
Start Page: 1394
End Page: 1397
Language: English
DOI: 10.1039/c8cc08769e
PUBMED: 30632546
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Jason S Lewis
    245 Lewis
  2. Sophie Poty
    7 Poty