Treatment of advanced prostate cancer Journal Article


Authors: Teo, M. Y.; Rathkopf, D. E.; Kantoff, P.
Article Title: Treatment of advanced prostate cancer
Abstract: The therapeutic landscape of prostate cancer has been transformed over the last decade by new therapeutics, advanced functional imaging, next-generation sequencing, and better use of existing therapies in early-stage disease. Until 2004, progression on androgen deprivation therapy for metastatic disease was treated with the addition of secondary hormonal manipulation; in the last decade, six systemic agents have been approved for the treatment of castration-resistant prostate cancer. We review clinical trials and survival benefit for these therapies and assess how the understanding of the disease shifted as these therapies were developed. We also discuss advances in noncastrate disease states, identification of biomarkers for prognosis and treatment selection, and opportunities in locoregional therapy to delay androgen deprivation therapy. © 2019 by Annual Reviews.
Keywords: systemic therapy; castration-resistant prostate cancer; crpc; mhspc; dynamic classification; metastatic hormone-sensitive prostate cancer
Journal Title: Annual Review of Medicine
Volume: 70
ISSN: 0066-4219
Publisher: Annual Reviews  
Date Published: 2019-01-01
Start Page: 479
End Page: 499
Language: English
DOI: 10.1146/annurev-med-051517-011947
PUBMED: 30691365
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Dana Elizabeth Rathkopf
    142 Rathkopf
  2. Min Yuen   Teo
    29 Teo
  3. Philip Wayne Kantoff
    62 Kantoff