Tissue effects after stereotactic body radiotherapy using Cyberknife for patients with abdominal malignancies Journal Article
| Authors: | Cupp, J. S.; Koong, A. C.; Fisher, G. A.; Norton, J. A.; Goodman, K. A. |
| Article Title: | Tissue effects after stereotactic body radiotherapy using Cyberknife for patients with abdominal malignancies |
| Abstract: | Aims: To report the tissue effects of treatment with single fraction stereotactic body radiotherapy (SBRT) using Cyberknife on malignant tumours of the abdomen and adjacent normal organs. Materials and methods: The data from four autopsies with unresectable pancreatic carcinoma and one lymph node excision from a case of recurrent neuroblastoma were reviewed for radiation-related tissue effects within the primary cancer and the normal organs within the radiation field. Results: Cases of unresectable pancreatic carcinoma consistently showed radiation-induced changes in both the primary tumour and the adjacent, non-malignant colorectal tissue. An additional case of lymph nodes exposed to stereotactic radiation showed typical radiation-related changes, including lymphocyte depletion and capsular fibrosis. Conclusions: A myriad of radiation-related tissue effects are seen after SBRT with Cyberknife. The changes parallel those reported after conventionally fractionated radiotherapy and suggest that the pathophysiological mechanisms of radiation-induced normal tissue damage are similar for biologically equivalent single and fractionated doses of radiotherapy. © 2007 The Royal College of Radiologists. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; middle aged; doxorubicin; gemcitabine; cancer radiotherapy; pancreatic neoplasms; lymph node metastasis; antineoplastic agent; lymph nodes; lymph node excision; lymphadenectomy; adenocarcinoma; cyclophosphamide; vincristine; radiation injury; radiation exposure; radiation response; pancreas carcinoma; abdomen; neuroblastoma; radiation dose fractionation; radiosurgery; stereotactic body radiotherapy; external beam radiotherapy; mesna; autopsy; hemicolectomy; radiation field; colon; lymphocyte depletion; cyberknife; rectum; abdominal neoplasms; abdominal cancer; pancreatic carcinoma; colon obstruction; colon ulcer |
| Journal Title: | Clinical Oncology |
| Volume: | 20 |
| Issue: | 1 |
| ISSN: | 0936-6555 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2008-02-01 |
| Start Page: | 69 |
| End Page: | 75 |
| Language: | English |
| DOI: | 10.1016/j.clon.2007.08.009 |
| PUBMED: | 17900882 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: CLIOE" - "Source: Scopus" |
