Variants in the ATM gene associated with a reduced risk of contralateral breast cancer Journal Article
| Authors: | Concannon, P.; Haile, R. W.; Bøorresen-Dale, A. L.; Rosenstein, B. S.; Gatti, R. A.; Teraoka, S. N.; Diep, A. T.; Jansen, L.; Atencio, D. P.; Langholz, B.; Capanu, M.; Liang, X.; Begg, C. B.; Thomas, D. C.; Bernstein, L.; Olsen, J. H.; Malone, K. E.; Lynch, C. F.; Anton-Culver, H.; Bernstein, J. L. |
| Article Title: | Variants in the ATM gene associated with a reduced risk of contralateral breast cancer |
| Abstract: | Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In this study, 708 women with asynchronous CBC served as cases and 1,397 women with unilateral breast cancer served as controls. ATM, a serinethreonine kinase, controls the cellular response to DNA double-strand breaks, and has been implicated in breast cancer risk. Complete mutation screening of the ATM gene in all 2,105 study participants identified 240 distinct sequence variants; only 15 were observed in >1% of subjects. Among the rare variants, deleterious alleles resulting in loss of ATM function were associated with a nonsignificant increase in risk of CBC. In contrast, carriers of common variants had a statistically significant reduction in risk of CBC. Four of these 15 variants were individually associated with a significantly decreased risk of second primary breast cancer [c.1899-55T>G, rate ratio (RR), 0.5; 95% confidence interval (CI), 0.3-0.8; c.3161C>G, RR, 0.5; 95% CI, 0.3-0.9; c.5558A>T, RR, 0.2; 95% CI, 0.1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53. © 2008 American Association for Cancer Research. |
| Keywords: | adult; controlled study; middle aged; dna binding protein; gene mutation; major clinical study; case control study; genetics; mutation; case-control studies; dna-binding proteins; clinical trial; cancer risk; united states; cell cycle protein; cell cycle proteins; allele; dna damage; gene; breast cancer; genetic variability; risk factors; gene function; antineoplastic activity; protein serine threonine kinase; breast neoplasms; protein p53; risk factor; protein-serine-threonine kinases; multicenter study; nucleotide sequence; breast tumor; tumor suppressor proteins; atm protein; double stranded dna break; neoplasms, second primary; dna mutational analysis; second cancer; tumor suppressor protein; denmark; gene activity; atm gene; variation (genetics) |
| Journal Title: | Cancer Research |
| Volume: | 68 |
| Issue: | 16 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2008-08-15 |
| Start Page: | 6486 |
| End Page: | 6491 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-08-0134 |
| PUBMED: | 18701470 |
| PROVIDER: | scopus |
| PMCID: | PMC2562548 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: CNREA" - "Source: Scopus" |
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