Evaluation of lymph nodes with RECIST 1.1 Journal Article


Authors: Schwartz, L. H.; Bogaerts, J.; Ford, R.; Shankar, L.; Therasse, P.; Gwyther, S.; Eisenhauer, E. A.
Article Title: Evaluation of lymph nodes with RECIST 1.1
Abstract: Lymph nodes are common sites of metastatic disease in many solid tumours. Unlike most metastases, lymph nodes are normal anatomic structures and as such, normal lymph nodes will have a measurable size. Additionally, the imaging literature recommends that lymph nodes be measured in the short axis, since the short axis measurement is a more reproducible measurement and predictive of malignancy. Therefore, the RECIST committee recommends that lymph nodes be measured in their short axis and proposes measurement values and rules for categorising lymph nodes as normal or pathologic; either target or non-target lesions. Data for the RECIST warehouse are presented to demonstrate the potential change in response assessment following these rules. These standardised lymph node guidelines are designed to be easy to implement, focus target lesion measurements on lesions that are likely to be metastatic and prevent false progressions due to minimal change in size. © 2008 Elsevier Ltd. All rights reserved.
Keywords: clinical trial; cancer growth; lymph node metastasis; paraaortic lymph node; lymph nodes; lymphatic metastasis; sensitivity and specificity; neoplasms; computer assisted tomography; tomography, x-ray computed; practice guideline; data base; lymph node; clinical evaluation; response evaluation criteria in solid tumor; practice guidelines as topic; solid tumours; guidelines; response criteria
Journal Title: European Journal of Cancer
Volume: 45
Issue: 2
ISSN: 0959-8049
Publisher: Elsevier Inc.  
Date Published: 2009-01-01
Start Page: 261
End Page: 267
Language: English
DOI: 10.1016/j.ejca.2008.10.028
PUBMED: 19091550
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 22" - "Export Date: 30 November 2010" - "CODEN: EJCAE" - "Source: Scopus"
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  1. Lawrence H Schwartz
    281 Schwartz