Inflammation-associated lysophospholipids as ligands for CDld-restricted T cells in human cancer Journal Article
| Authors: | Chang, D. H.; Deng, H.; Matthews, P.; Krasovsky, J.; Ragupathi, G.; Spisek, R.; Mazumder, A.; Vesole, D. H.; Jagannath, S.; Dhodapkar, M. V. |
| Article Title: | Inflammation-associated lysophospholipids as ligands for CDld-restricted T cells in human cancer |
| Abstract: | CD 1d-restricted T cells have been implicated in the pathogenesis of several chronic inflammatory states. However, the nature of the specific ligands recognized by these cells in vivo in patients with inflammatory or malignant diseases remains unknown. We took a biochemical approach to directly isolate and characterize the nature of CD1d-binding ligands from the plasma of myeloma patients. Characterization of these ligands revealed several lysophosphatidylcholine (LPC) species. Human LPC-CD1d dimer binding cells areT-cell receptorαβ+ T cells but predominantly Vα24~Vβ11-. Cytokine secretion by LPC-specific T cells is skewed toward IL-13 secretion, and the frequencies of these cells are increased in myeloma patients relative to healthy donors. These data identify a distinct population of human CD1d-restricted T cells specific for inflammation-associated lysolipids and suggest a novel mechanism for inflammation mediated immune regulation in human cancer. © 2008 by The American Society of Hematology. |
| Keywords: | controlled study; human cell; t lymphocyte; t-lymphocytes; protein analysis; metabolism; multiple myeloma; interleukin 13; inflammation; protein binding; pathology; cell population; t lymphocyte receptor; t lymphocyte receptor beta chain; immunology; lymphocyte activation; t-cell antigen receptor specificity; ligand; ligands; natural killer cell; killer cells, natural; cd3+ t lymphocyte; cytokine release; lymphocyte antigen receptor; receptors, antigen, t-cell, alpha-beta; myeloma; secretion; protein isolation; cd1d antigen; t lymphocyte receptor alpha chain; interleukin-13; lysophospholipids; lysophosphatidylcholine; lysophospholipid; cd1 antigen; antigens, cd1; lysophosphatidylcholines |
| Journal Title: | Blood |
| Volume: | 112 |
| Issue: | 4 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2008-08-15 |
| Start Page: | 1308 |
| End Page: | 1316 |
| Language: | English |
| DOI: | 10.1182/blood-2008-04-149831 |
| PUBMED: | 18535199 |
| PROVIDER: | scopus |
| PMCID: | PMC2515141 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 27" - "Export Date: 17 November 2011" - "CODEN: BLOOA" - "Source: Scopus" |
