A prospective observational study examining quality of life in patients with malignant gastric outlet obstruction Journal Article
| Authors: | Schmidt, C.; Gerdes, H.; Hawkins, W.; Zucker, E.; Zhou, Q.; Riedel, E.; Jaques, D.; Markowitz, A.; Coit, D.; Schattner, M. |
| Article Title: | A prospective observational study examining quality of life in patients with malignant gastric outlet obstruction |
| Abstract: | Background: Gastric outlet obstruction (GOO) often complicates advanced malignancy. Palliative options include surgical bypass, endoscopic stent, percutaneous gastrostomy (PEG), or percutaneous jejunostomy (PEJ). Methods: We enrolled 50 patients with GOO secondary to unresectable primary or metastatic cancer in a study examining palliative interventions. Validated instruments assessed quality of life (QOL) at baseline, 1 month, and 3 months following intervention. Results: Median overall survival was 64 days. A shorter hospital stay and trend to lower mortality were observed after stent placement; solid food intake and rates of secondary intervention were comparable. Both stent and surgical bypass were associated with acceptable QOL outcomes. Fifteen patients refused participation at 1 month and 28 died of disease before 3 months, so 10 patients completed all surveys. Conclusions: Although malignant GOO is associated with poor survival, there are reasonable alternatives for palliation. QOL studies are difficult to complete in this population due to severity of illness and short life expectancy. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | adult; cancer chemotherapy; clinical article; controlled study; treatment outcome; survival rate; clinical trial; mortality; cancer radiotherapy; follow-up studies; prospective study; prospective studies; palliative care; metastasis; quality of life; controlled clinical trial; palliative therapy; time factors; gastrointestinal neoplasms; questionnaire; patient participation; length of stay; disease progression; stent; observational study; new york; endoscopy; gastrostomy; abdominal neoplasm; gastric outlet obstruction; intestine bypass; jejunostomy; stomach obstruction; endoscopy, gastrointestinal |
| Journal Title: | American Journal of Surgery |
| Volume: | 198 |
| Issue: | 1 |
| ISSN: | 0002-9610 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-07-01 |
| Start Page: | 92 |
| End Page: | 99 |
| Language: | English |
| DOI: | 10.1016/j.amjsurg.2008.09.030 |
| PUBMED: | 19482259 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: AJSUA" - "Source: Scopus" |
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