Circulating HLA-DR+ natural killer cells have potent lytic ability and weak antigen-presenting cell function Journal Article

   

Authors:	Burt, B. M.; Plitas, G.; Nguyen, H. M.; Stableford, J. A.; Bamboat, Z. M.; DeMatteo, R. P.
Article Title:	Circulating HLA-DR+ natural killer cells have potent lytic ability and weak antigen-presenting cell function
Abstract:	Whether a freshly isolated immune cell can be equipped with both natural killing and antigen-presenting cell (APC) function has recently become controversial in mice. We sought to probe the existence of a candidate human cell with these properties by searching for cells in healthy subjects that co-express APC surface molecules and NK cell receptors. We have found that CD3-CD14-CD19- mononuclear cells of human blood, spleen, liver, and lymph nodes contain two distinct populations of cells that co-express HLA-DR (DR) and CD56. Circulating CD56+ cells expressing high levels of DR were phenotypically and functionally similar to conventional CD56-dendritic cells (DC). Furthermore, we demonstrate here that a separate cohort of CD56+ cells that express low levels of DR are NK cells that possess dual function as potent killers endowed with weak APC function. © 2008 American Society for Histocompatibility and Immunogenetics.
Keywords:	controlled study; human tissue; human cell; cd3 antigen; antigen expression; phenotype; cell function; spleen; dendritic cell; drug potency; blood; liver; antigen presentation; dendritic cells; mononuclear cell; lymph node; hla dr antigen; hla-dr antigens; natural killer cell; killer cells, natural; natural killer cell receptor; cytolysis; cytotoxicity, immunologic; genetic procedures; cell separation; antigen presenting cell; cd19 antigen; cd45 antigen; cd14 antigen; lymphocyte subsets; cd56 antigen; antigen-presenting cell; natural killer cells; antigens, cd56
Journal Title:	Human Immunology
Volume:	69
Issue:	8
ISSN:	0198-8859
Publisher:	Elsevier Inc.
Date Published:	2008-08-01
Start Page:	469
End Page:	474
Language:	English
DOI:	10.1016/j.humimm.2008.06.009
PUBMED:	18640163
PROVIDER:	scopus
PMCID:	PMC2566547
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-50949085172&partnerID=40&md5=17d4e81e72d99c9c54b2627353a0f0df
Notes:	--- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: HUIMD" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/14112