Is pleomorphic lobular carcinoma really a distinct clinical entity? Journal Article
| Authors: | Buchanan, C. L.; Flynn, L. W.; Murray, M. P.; Darvishian, F.; Cranor, M. L.; Fey, J. V.; King, T. A.; Tan, L. K.; Sclafani, L. M. |
| Article Title: | Is pleomorphic lobular carcinoma really a distinct clinical entity? |
| Abstract: | Background: Attempts to define the clinical behavior of pleomorphic lobular carcinoma (PLC) have been limited to small series, and clinical management strategies have yet to be established. We describe our experience with PLC as compared to classic ILC and invasive ductal carcinoma (IDC). Methods: From 9/1996 to 5/2003, clinical and histopathologic data for 5,635 patients undergoing primary surgical treatment and sentinel lymph node biopsy for breast cancer were collected. Four hundred eighty one (8.5%) patients were diagnosed with ILC; 3,978 (70.6%) with IDC. Of those with ILC, 356 (74%) patients had material available for pathologic re-review and comprise our study population: 52 were classified as PLC; 298 were classified as classic ILC; and 6 cases were reclassified as IDC. We compared clinical, pathologic, and treatment factors for patients with PLC, ILC, and IDC using the Wilcoxon rank sum and Fisher's exact tests. Results: PLC were larger than ILC and IDC (20 vs. 15 vs. 13, P < 0.001), had more positive nodes (median 1 vs. 0 vs. 0, P < 0.05) and more frequently required mastectomy (63.5% vs. 38.7% vs. 28.8%, P < 0.001). In addition, more patients with PLC had developed metastatic disease compared to patients with ILC (11.5% vs. 3.7%, P < 0.05). Conclusions: These findings suggest that PLC is a distinct clinical entity that presents at a more advanced stage and may require more aggressive surgical and adjuvant treatment. © 2008 Wiley-Liss, Inc. |
| Keywords: | immunohistochemistry; adult; human tissue; aged; aged, 80 and over; middle aged; cancer surgery; major clinical study; histopathology; cancer recurrence; comparative study; cancer incidence; neoplasm staging; sentinel lymph node biopsy; metastasis; mastectomy; tumor volume; recurrence; breast neoplasms; breast carcinoma; neoplasm invasiveness; cancer classification; fisher exact test; carcinoma, intraductal, noninfiltrating; cancer morphology; rank sum test; carcinoma, ductal, breast; carcinoma, lobular; pleomorphic lobular carcinoma; classic lobular carcinoma; invasive ductal carcinoma; invasive lobular carcinoma |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 98 |
| Issue: | 5 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-10-01 |
| Start Page: | 314 |
| End Page: | 317 |
| Language: | English |
| DOI: | 10.1002/jso.21121 |
| PUBMED: | 18668643 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: JSONA" - "Source: Scopus" |
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