Multiple myeloma: Primary bone tumor with systemic manifestations Journal Article
| Authors: | Bilsky, M. H.; Azeem, S. |
| Article Title: | Multiple myeloma: Primary bone tumor with systemic manifestations |
| Abstract: | Multiple myeloma is a plasma cell dyscrasia that frequently involves the bone marrow of the spine. These tumors are typically chemosensitive and radiation sensitive. Multiple myeloma promotes osteoclast activation and osteoblast inhibition, resulting in osteolysis of the vertebral bodies and subsequent compression fractures. Rarely is open surgery for decompression and instrumentation indicated. The presence of diffuse osteoporosis in patients with multiple myeloma increases the probability of failed fixation in this population. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | bone tumor; osteolysis; primary tumor; treatment failure; clinical feature; review; treatment indication; multiple cycle treatment; multiple myeloma; myalgia; bisphosphonic acid derivative; diagnostic imaging; arthralgia; drug cost; laboratory test; decompression surgery; spinal cord compression; spine; spinal neoplasms; comorbidity; flu like syndrome; osteoclast; osteoporosis; diphosphonates; bone necrosis; jaw disease; zoledronic acid; osteoblast; neurosurgical procedures; spinal fractures; pamidronic acid; vertebra body; clodronic acid; ibandronic acid; systemic disease; plasma cell dyscrasia; poly(methyl methacrylate); compression fracture |
| Journal Title: | Neurosurgery Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1042-3680 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2008-01-01 |
| Start Page: | 31 |
| End Page: | 40 |
| Language: | English |
| DOI: | 10.1016/j.nec.2007.09.001 |
| PUBMED: | 18156045 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: NCNAF" - "Source: Scopus" |
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