Etoposide plus carboplatin or cisplatin in good-risk patients with germ cell tumors: A randomized comparison Conference Paper
| Authors: | Bosl, G. J.; Bajorin, D. F. |
| Title: | Etoposide plus carboplatin or cisplatin in good-risk patients with germ cell tumors: A randomized comparison |
| Conference Title: | Fox Chase Cancer Center Workshop on the Role of Platinum Compounds in Cancer Treatment |
| Abstract: | Two hundred sixty-five evaluable patients were randomized to receive either carboplatin/etoposide (131 patients) or cisplatin/etoposide (134 patients). Among the carboplatin-treated patients, 115 (88%) achieved a complete remission, compared with 121 (90%) of patients receiving cisplatin. In the carboplatin group, however, 16 patients (12%) relapsed following complete remission, in contrast to four (3%) of those receiving cisplatin. Thus, the total number of unfavorable events (incomplete response + relapse) was 32 (24%) in the carboplatin arm, compared with 17 (13%) in the cisplatin arm (P = .02). In addition, patients receiving carboplatin had a greater likelihood of being hospitalized for neutropenia and fever (P = .016) and had lower platelet nadirs (P < .001). It was concluded that carboplatin administered at the dose and schedule used in this clinical trial resulted in an inferior event-free survival rate and worse toxicity than cisplatin, and is not recommended for use in general practice. |
| Keywords: | adolescent; adult; controlled study; aged; middle aged; survival rate; major clinical study; clinical trial; neutropenia; cancer recurrence; cisplatin; dose response; conference paper; carboplatin; controlled clinical trial; anemia; etoposide; randomized controlled trial; thrombocytopenia; antineoplastic combined chemotherapy protocols; peripheral neuropathy; drug administration schedule; fever; cancer regression; testicular neoplasms; thrombocyte count; remission induction; germ cell tumor; seminoma; intravenous drug administration; ototoxicity; germinoma; humans; human; male; priority journal |
| Journal Title | Seminars in Oncology |
| Volume: | 21 |
| Issue: | 5 Suppl. 12 |
| Conference Dates: | 1993 Feb 24-28 |
| Conference Location: | Kona, HI |
| ISBN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-10-01 |
| Start Page: | 61 |
| End Page: | 64 |
| Language: | English |
| PUBMED: | 7992068 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 14 January 2019 -- Source: Scopus |
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