A phase II trial of paclitaxel (Taxol) in advanced esophageal cancer: Preliminary report Conference Paper
| Authors: | Kelsen, D.; Ajani, J.; Ilson, D.; Daugherty, K.; Pazdur, R. |
| Title: | A phase II trial of paclitaxel (Taxol) in advanced esophageal cancer: Preliminary report |
| Conference Title: | Newest Clinical Approaches with Paclitaxel (Taxol) |
| Abstract: | A cooperative, phase II single-arm trial was conducted at two large tertiary referral cancer centers to evaluate the antineoplastic activity and toxicities of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) in the treatment of patients with advanced esophageal cancer. The drug was given at a dose of 250 mg/m2 as a 24-hour continuous infusion. Repeat courses were given at 21-day intervals. De-escalation was based primarily on myelosuppression. All patients received recombinant human granulocyte colony- stimulating factor to minimize the risk of neutropenic fever. The primary goal of the study was tumor response. In the trial, which is ongoing, 42 patients have been assessed to date. Adenocarcinoma was the predominant histology in 30 patients, while epidermoid cancer was seen in 13 patients. Paclitaxel was identified as an active agent. Thirty percent of patients with adenocarcinoma and 25% of the smaller group with epidermoid carcinoma have had partial remissions. Complete remissions have not been seen to date. The median duration of response was 9 weeks. The major toxicity was myelosuppression; II patients required admission for neutropenic fever on 13 different occasions. Paclitaxel is an active drug in the treatment of esophageal cancer. Currently, there does not appear to be a difference in response on the basis of histologic subtype. Further studies with paclitaxel in combination with other drugs (eg, cisplatin and 5-fluorouracil), on different treatment schedules, and as part of multimodality therapy are indicated. |
| Keywords: | adult; clinical article; treatment outcome; aged; clinical trial; histopathology; neutropenia; squamous cell carcinoma; carcinoma, squamous cell; dose response; conference paper; paclitaxel; adenocarcinoma; phase 2 clinical trial; bone marrow suppression; antineoplastic activity; cancer regression; multicenter study; recombinant proteins; recombinant granulocyte colony stimulating factor; esophagus cancer; alopecia; granulocyte colony-stimulating factor; esophageal neoplasms; intravenous drug administration; middle age; subcutaneous drug administration; human; male; female; priority journal |
| Journal Title | Seminars in Oncology |
| Volume: | 21 |
| Issue: | 5 Suppl. 8 |
| Conference Dates: | 1993 Nov 15 |
| Conference Location: | Jerusalem, Israel |
| ISBN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-10-01 |
| Start Page: | 44 |
| End Page: | 48 |
| Language: | English |
| PUBMED: | 7524158 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 14 January 2019 -- Source: Scopus |
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