Chemotherapy for cisplatin-resistant germ cell tumors Journal Article
| Authors: | Murphy, B. A.; Motzer, R. J.; Bosl, G. J. |
| Article Title: | Chemotherapy for cisplatin-resistant germ cell tumors |
| Abstract: | Effective first- and second-line salvage chemotherapies using ifosfamide-based regimens or high dose chemotherapy followed by autologous bone marrow transplantation (AUBMT) are available for patients with germ cell tumors (GCT) in whom a durable complete response to initial cisplatin-based therapy is not achieved. Models have been developed that identify 'poor risk' patients who are unlikely to have prolonged survival after cisplatin-based induction chemotherapy. Intensive initial chemotherapy regimens are currently being investigated in this group of patients in an attempt to increase response and survival rates. |
| Keywords: | cancer survival; review; cisplatin; doxorubicin; cancer combination chemotherapy; multimodality cancer therapy; drug megadose; carboplatin; etoposide; cyclophosphamide; drug resistance; ifosfamide; vinblastine; dactinomycin; bleomycin; vindesine; germ cell tumor; retinoic acid; intravenous drug administration; mitoguazone; oral drug administration; autologous bone marrow transplantation; prognosis; human; male; priority journal; iproplatin |
| Journal Title: | Problems in Urology |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 0889-471X |
| Publisher: | J.B. Lippincott Co. |
| Date Published: | 1994-03-01 |
| Start Page: | 127 |
| End Page: | 140 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
