| Abstract: |
Serum tumor markers, including alphafetoprotein and human chorionic gonadotropin, are critical to the choice of therapy and monitoring of patients with germ cell tumors. i(12p) is a specific chromosomal marker for germ cell tumors that is diagnostically useful, of possible prognostic importance, and detectable by both conventional and molecular cytogenetic techniques. A variety of other molecular genetic markers are under study, in order to contribute to the understanding of normal and aberrant differentiation and to understand their relevance as tumor markers. |
| Keywords: |
cancer survival; review; cisplatin; cancer combination chemotherapy; cancer grading; antigen expression; carboplatin; etoposide; tumor markers, biological; cyclophosphamide; patient monitoring; tumor antigen; tumor marker; prediction; vinblastine; antigen detection; diagnosis; dactinomycin; bleomycin; teratoma; lactate dehydrogenase; neoplasms, germ cell and embryonal; germ cell tumor; mediastinum tumor; choriocarcinoma; embryonal carcinoma; genetic markers; chromosome 12p; non seminomatous germinoma; antigens, differentiation; alpha fetoprotein; chorionic gonadotropin; alkaline phosphatase placenta isoenzyme; keratin; transformation, genetic; monitoring, physiologic; plasma half life; plasma clearance; isochromosome; prognosis; human; priority journal; support, u.s. gov't, p.h.s.; blood group antigen
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