Butyrate as a differentiating agent: Pharmacokinetics, analogues and current status Journal Article

  


Authors: Newmark, H. L.; Lupton, J. R.; Young, C. W.
Article Title: Butyrate as a differentiating agent: Pharmacokinetics, analogues and current status
Abstract: The field of butyrate-induced differentiation of neoplastic and non-neoplastic cells is reviewed and possible clinical correlations considered with regard to butyrate, butyrate prodrugs and butyrate analogues. These topics are discussed from the point of view of the concentrations required in vitro for biologic effect, and likely pharmacokinetic behavior in vivo. © 1994.
Keywords: leukemia; drug activity; antineoplastic agents; cell differentiation; tumor cell; thalassemia; short survey; butyric acid; sickle cell anemia; anemia, sickle cell; butyric acid derivative; butyrates; drug analog; human; priority journal; butyrate; tributyrin; butyramide; butyrate esters
Journal Title: Cancer Letters
Volume: 78
Issue: 1-3
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 1994-04-01
Start Page: 1
End Page: 5
Language: English
DOI: 10.1016/0304-3835(94)90023-x
PUBMED: 8180951
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028260120&doi=10.1016%2f0304-3835%2894%2990023-X&partnerID=40&md5=962a81f11621720d33a37598da727f1e
Notes: Source: Scopus
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MSK Authors
  1. Charles W Young
    82 Young
  2. Harold L. Newmark
    61 Newmark
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