Constructing and deconstructing cancers using human pluripotent stem cells and organoids Editorial

   


Authors: Smith, R. C.; Tabar, V.
Title: Constructing and deconstructing cancers using human pluripotent stem cells and organoids
Abstract: Cell lines and animal models have provided the foundation of cancer research for many years. However, human pluripotent stem cells (hPSCs) and organoids are increasingly enabling insights into tumor development, progression, and treatment. Here, we review recent studies using hPSCs to elucidate the reciprocal roles played by genetic alterations and cell identity in cancer formation. We also review studies using human organoids as models that recapitulate both intra- and inter-tumoral heterogeneity to gain new insights into tumorigenesis and treatment responses. Finally, we highlight potential opportunities for cancer research using hPSC-derived organoids and genome editing in the future. © 2018 Elsevier Inc. Smith and Tabar discuss how models of human pluripotent stem cells (hPSCs) and organoids provide insights into tumor development, progression, and treatment, as well as potential opportunities for cancer research using hPSC-derived organoids and genome editing. © 2018 Elsevier Inc.
Keywords: controlled study; treatment response; human cell; review; drug screening; cancer research; carcinogenesis; pluripotent stem cell; pluripotent stem cells; differentiation; tumor heterogeneity; disease modeling; identity; cell identity; cell-of-origin; cancer; human; genome editing; organoids; organoid; gene editing
Journal Title: Cell Stem Cell
Volume: 24
Issue: 1
ISSN: 1934-5909
Publisher: Cell Press  
Date Published: 2019-01-03
Start Page: 12
End Page: 24
Language: English
DOI: 10.1016/j.stem.2018.11.012
PUBMED: 30581078
PROVIDER: scopus
PMCID: PMC6516073
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059496126&doi=10.1016%2fj.stem.2018.11.012&partnerID=40&md5=54d83f3623ff1c09b742b2219612aa73
Notes: Review -- Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Viviane S Tabar
    224 Tabar
  2. Ryan Christopher Smith
    4 Smith
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