Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients Journal Article
| Authors: | Greenlee, H.; Shi, Z.; Hibshoosh, H.; Giri, D. D.; Ahmed, A.; Williams, S.; Falcone, D. J.; Winston, L. A.; Zhou, X. K.; Hudis, C. A.; Hershman, D. L.; Dannenberg, A. J.; Iyengar, N. M. |
| Article Title: | Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients |
| Abstract: | Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm2 Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5-<25.0 kg/m2), overweight (25.0-<30.0 kg/m2), class I obesity (30.0-<35.0 kg/m2), and class II-III obesity (35.0 kg/m2 or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36-96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II-III obesity; Ptrend <0.01). Severe BWATi (>0.27 CLS-B/cm2) was associated with higher BMI (Ptrend = 0.046) and greater adipocyte diameter (P = 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all P < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations. ©2018 American Association for Cancer Research. |
| Journal Title: | Cancer Prevention Research |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1940-6207 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2019-01-01 |
| Start Page: | 21 |
| End Page: | 30 |
| Language: | English |
| DOI: | 10.1158/1940-6207.Capr-18-0207 |
| PUBMED: | 30404870 |
| PROVIDER: | scopus |
| PMCID: | PMC6663483 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2019 -- Source: Scopus |
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