Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab Journal Article


Authors: Thomas, A.; Rosenblum, M.; Karimi, S.; DeAngelis, L. M.; Omuro, A.; Kaley, T. J.
Article Title: Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab
Abstract: Interpretation of MRI abnormalities in patients with malignant gliomas (MG) treated with bevacizumab is challenging. Recent reports describe quantitative analyses of diffusion-weighted imaging abnormalities not available in standard clinical settings, to differentiate tumor recurrence from treatment necrosis. We retrospectively reviewed bevacizumab treated MG patients who underwent surgery or autopsy to correlate radiographic recurrence patterns with pathologic findings. 32 patients with MG (26 glioblastoma, three anaplastic astrocytoma and three anaplastic oligodendroglioma) were identified. Recurrence patterns: local enhancing (n = 23), distant enhancing (n = 1), nonenhancing (n = 7) and leptomeningeal (n = 1). HISTOLOGY: tumor (n = 25), mixed tumor/necrosis (n = 5) and all necrosis (n = 2). On diffusion-weighted imaging, 5/32 had restricted diffusion (three mixed and two necrosis). Irrespective of radiographic recurrence pattern, tumor was found in 94% of cases. Restricted diffusion correlated with necrosis.
Keywords: bevacizumab; pathology; necrosis; glioblastoma; malignant glioma
Journal Title: CNS Oncology
Volume: 7
Issue: 1
ISSN: 2045-0907
Publisher: Future Medicine  
Date Published: 2018-01-01
Start Page: 7
End Page: 13
Language: English
DOI: 10.2217/cns-2017-0025
PUBMED: 29388793
PROVIDER: scopus
PMCID: PMC6001559
DOI/URL:
Notes: Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Marc Rosenblum
    424 Rosenblum
  2. Antonio Marcilio Padula Omuro
    204 Omuro
  3. Sasan Karimi
    115 Karimi
  4. Thomas Kaley
    154 Kaley
  5. Alissa A Thomas
    17 Thomas