Reductive desilanolation as a route to benzonitriles. An application to a concise synthesis of the aromatic sector of calicheamicin Journal Article
| Authors: | Olson, S. H.; Danishefsky, S. J. |
| Article Title: | Reductive desilanolation as a route to benzonitriles. An application to a concise synthesis of the aromatic sector of calicheamicin |
| Abstract: | The TMS-cyanohydrins of quinones undergo reductive desilanolation in the presence of samarium iodide to form hydroxybenzonitriles. Benzoquinone 1 was converted to the hexasubstituted aromatic fragment of calicheamicin 4 by this method. © 1994. |
| Keywords: | unclassified drug; drug synthesis; reaction analysis; nitrile; article; calicheamicin derivative; benzonitrile derivative |
| Journal Title: | Tetrahedron Letters |
| Volume: | 35 |
| Issue: | 43 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1994-10-24 |
| Start Page: | 7901 |
| End Page: | 7904 |
| Language: | English |
| DOI: | 10.1016/0040-4039(94)80006-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Tetrahedron Lett. -- Cited By :7 -- Export Date: 14 January 2019 -- Article -- CODEN: TELEA -- Source: Scopus |
