Gene therapy utilizing drug resistance genes: A review Journal Article

  


Authors: Banerjee, D.; Zhao, S. C.; Li, M. X.; Schweitzer, B. I.; Mineishi, S.; Bertino, J. R.
Article Title: Gene therapy utilizing drug resistance genes: A review
Abstract: The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed. Copyright © 1994 AlphaMed Press
Keywords: hydroxyurea; review; doxorubicin; nonhuman; antineoplastic agents; paclitaxel; chemotherapy; methotrexate; antineoplastic agent; polymerase chain reaction; phenotype; animal; mice; gene; bone marrow cells; cd34 antigen; etoposide; camptothecin; cyclophosphamide; hematopoietic stem cell transplantation; drug resistance; gene transfer; animalia; genetic vectors; rna; cancer regression; whole body radiation; dna; virus rna; dogs; gene therapy; hematopoietic stem cells; stem cells; malignant neoplastic disease; vinca alkaloid; hematopoietic stem cell; genetic disorder; dna topoisomerase (atp hydrolysing); dihydrofolate reductase; thymidylate synthase; tetrahydrofolate dehydrogenase; bone marrow transplantation; floxuridine; tubulin; growth factor; granulocyte colony stimulating factor; multidrug resistance; bone marrow toxicity; p-glycoprotein; retrovirus; colony forming unit gm; dna topoisomerase; virus protein; cho cells; beta globin; southern blotting; glycoprotein p; calcium phosphate; ribonucleotide reductase; haplorhini; adenosine deaminase; unidentified retrovirus; human; hamsters; vinca; drug resistance genes
Journal Title: Stem Cells
Volume: 12
Issue: 4
ISSN: 1066-5099
Publisher: AlphaMed Press  
Date Published: 1994-07-01
Start Page: 378
End Page: 385
Language: English
DOI: 10.1002/stem.5530120404
PROVIDER: scopus
PUBMED: 7951004
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028023141&doi=10.1002%2fstem.5530120404&partnerID=40&md5=75558aae17ae354531072b756123d223
Notes: Stem Cells -- Cited By :31 -- Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. Debabrata Banerjee
    136 Banerjee
  2. Joseph Bertino
    363 Bertino
  3. Shi-Cheng Zhao
    42 Zhao
  4. Shin Mineishi
    22 Mineishi
  5. Barry I. Schweitzer
    22 Schweitzer
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