AMI-227-enhanced MR lymphography: Usefulness for differentiating reactive from tumor-bearing lymph nodes Journal Article

  


Authors: Vassallo, P.; Matei, C.; Heston, W. D. W.; McLachlan, S. J.; Koutcher, J. A.; Castellino, R. A.
Article Title: AMI-227-enhanced MR lymphography: Usefulness for differentiating reactive from tumor-bearing lymph nodes
Abstract: PURPOSE: To determine the value of magnetic resonance (MR) lymphography enhanced with AMI-227, a superparamagnetic reticuloendothelial-system- specific contrast agent, to distinguish normal and reactive from tumor- bearing lymph nodes. MATERIALS AND METHODS: Mature male Copenhagen rats were inoculated with cell suspensions of R3327-MATLyLu rat prostate carcinoma (n = 16) or Complete Freund Adjuvant (n = 15) to generate ipsilateral popliteal lymph node metastases or lymphadenitis. At 12-14 days after inoculation, T1- and T2-weighted MR images of bilateral popliteal areas were obtained before and 24 hours after administration of AMI-227 (dose, 30 μmol Fe/kg). The contralateral popliteal nodes served as controls. Contrast-to-noise ratios (C/Ns) between the nodes and adjacent muscle were calculated in pre- and postcontrast images. Subsequently, bilateral popliteal nodes were excised. RESULTS: AMI-227 resulted in decreased C/N in reactive nodes (T1-weighted, - 186% ± 90% [standard deviation]; T2-weighted, -205% ± 96%) and normal nodes (n = 7) (T1-weighted, -306% ± 82; T2-weighted, -350% ± 96). C/N remained unchanged or increased (T1-weighted, 88% ± 92; T2-weighted, 306% ± 256) (P < .05). CONCLUSION: Differences in AMI-227 uptake at MR imaging may help differentiate tumor-bearing from non-tumor-bearing nodes.
Keywords: controlled study; nonhuman; lymph node metastasis; animal cell; animal tissue; signal noise ratio; animal experiment; animal model; lymphatic system; diagnostic value; contrast enhancement; rat; iron; lymphadenitis; contrast medium; prostate adenocarcinoma; nuclear magnetic resonance; intravenous drug administration; ultrasmall superparamagnetic iron oxide; isoflurane; iron oxide; freund adjuvant; lymphography; magnetic resonance (mr); lymph follicle; iron dextran; lymph node hyperplasia; subcutaneous drug administration; male; priority journal; article
Journal Title: Radiology
Volume: 193
Issue: 2
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1994-11-01
Start Page: 501
End Page: 506
Language: English
DOI: 10.1148/radiology.193.2.7972768
PROVIDER: scopus
PUBMED: 7972768
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027946475&doi=10.1148%2fradiology.193.2.7972768&partnerID=40&md5=2cadf34b0f41020fb5cdf05f5a5ed545
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MSK Authors
  1. Warren Heston
    136 Heston
  2. Jason A Koutcher
    278 Koutcher
  3. Cornelia Matei
    35 Matei
  4. Ronald A Castellino
    34 Castellino
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