Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas Journal Article
| Authors: | Weaver-Feldhaus, J.; Gruis, N. A.; Neuhausen, S.; Le Paslier, D.; Stockert, E.; Skolnick, M. H.; Kamb, A. |
| Article Title: | Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas |
| Abstract: | The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the α- interferon gene cluster. |
| Keywords: | gene cluster; human cell; sequence deletion; comparative study; melanoma; chromosomes, human, pair 9; tumor cells, cultured; cloning, molecular; gene mapping; tumor suppressor gene; genetic susceptibility; homozygote; genetic marker; genes, tumor suppressor; linkage (genetics); genetic markers; gene location; chromosome mapping; chromosome 9; human; priority journal; article; support, u.s. gov't, p.h.s.; chromosomes, artificial, yeast; sequence tagged sites |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 91 |
| Issue: | 16 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1994-08-02 |
| Start Page: | 7563 |
| End Page: | 7567 |
| Language: | English |
| DOI: | 10.1073/pnas.91.16.7563 |
| PROVIDER: | scopus |
| PMCID: | PMC44442 |
| PUBMED: | 8052620 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: PNASA C2 -- Source: Scopus |
