Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas Journal Article


Authors: Weaver-Feldhaus, J.; Gruis, N. A.; Neuhausen, S.; Le Paslier, D.; Stockert, E.; Skolnick, M. H.; Kamb, A.
Article Title: Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas
Abstract: The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the α- interferon gene cluster.
Keywords: gene cluster; human cell; sequence deletion; comparative study; melanoma; chromosomes, human, pair 9; tumor cells, cultured; cloning, molecular; gene mapping; tumor suppressor gene; genetic susceptibility; homozygote; genetic marker; genes, tumor suppressor; linkage (genetics); genetic markers; gene location; chromosome mapping; chromosome 9; human; priority journal; article; support, u.s. gov't, p.h.s.; chromosomes, artificial, yeast; sequence tagged sites
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 91
Issue: 16
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1994-08-02
Start Page: 7563
End Page: 7567
Language: English
DOI: 10.1073/pnas.91.16.7563
PROVIDER: scopus
PMCID: PMC44442
PUBMED: 8052620
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- CODEN: PNASA C2 -- Source: Scopus
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