Nitric oxide and opioid tolerance Journal Article

  


Authors: Babey, A. M.; Kolesnikov, Y.; Cheng, J.; Inturrisi, C. E.; Trifilletti, R. R.; Pasternak, G. W.
Article Title: Nitric oxide and opioid tolerance
Abstract: Under conditions in which NG-nitro-l-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS levels with chronic morphine administration reveal no change. Total NOS activity in both brainstem and cerebellum homogenates is unchanged, as are levels of NOS mRNA in a variety of brain regions. l-Arginine, the precursor of nitric oxide (NO), accelerates tolerance when coadministered with morphine and when given alone l-arginine decreases morphine's potency. Administration of l-arginine alone for 3-10 days shifts morphine's dose-response curve over 2-fold to the right while d-arginine is without effect, as is daily administration of l-arginine along with the NOS inhibitor NOArg. Thus, chronic l-arginine induces "tolerance" in opioid naive mice through NOS. Together, our data indicate an important role for NO in the modulation of opioid analgesia. © 1994.
Keywords: controlled study; nonhuman; mouse; animal; mice; animal tissue; animal experiment; animal model; messenger rna; rna, messenger; morphine; analgesia; drug tolerance; mu opiate receptor; brain region; arginine; nitric oxide synthase; morphine tolerance; nitroarginine; reaction time; nitric oxide; kappa opiate receptor; nitric-oxide synthase; brain chemistry; intraperitoneal drug administration; mu receptor; subcutaneous drug administration; narcotics; intracerebroventricular drug administration; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; kappa receptor; n(g) nitroarginine; ng-nitroarginine methyl ester; dextro arginine; amino acid oxidoreductases; nitro-arginine
Journal Title: Neuropharmacology
Volume: 33
Issue: 11
ISSN: 0028-3908
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 1994-11-01
Start Page: 1463
End Page: 1470
Language: English
DOI: 10.1016/0028-3908(94)90050-7
PROVIDER: scopus
PUBMED: 7532830
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028051645&doi=10.1016%2f0028-3908%2894%2990050-7&partnerID=40&md5=aa5453c40ce4700d7573490779e586d7
Notes: Export Date: 14 January 2019 -- Article -- CODEN: NEPHB C2 -- Source: Scopus
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MSK Authors
  1. Yuri Alexei Kolesnikov
    34 Kolesnikov
  2. Charles E Inturrisi
    51 Inturrisi
  3. Gavril W Pasternak
    414 Pasternak
  4. Jie Cheng
    14 Cheng
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