Mechanism of activation of the TGF-β receptor Journal Article
| Authors: | Wrana, J. L.; Attisano, L.; Wieser, R.; Ventura, F.; Massagué, J. |
| Article Title: | Mechanism of activation of the TGF-β receptor |
| Abstract: | Transforming growth factor-β (TGF-β) signals by contacting two distantly related transmem-brane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-β binds directly to receptor II, which is a constitutively active kinase. Bound TGF-β is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade. © 1994 Nature Publishing Group. |
| Keywords: | signal transduction; protein phosphorylation; nonhuman; animal cell; animal; transforming growth factor beta; cell line; transfection; protein serine threonine kinase; phosphorylation; animalia; amino acid sequence; molecular sequence data; isotope labeling; cell membrane; receptors, transforming growth factor beta; receptor protein-tyrosine kinases; receptor binding; mink; cytokine receptor; growth factor receptor; phosphorus 32; phosphorus radioisotopes; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s. |
| Journal Title: | Nature |
| Volume: | 370 |
| Issue: | 6488 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1994-08-04 |
| Start Page: | 341 |
| End Page: | 347 |
| Language: | English |
| DOI: | 10.1038/370341a0 |
| PROVIDER: | scopus |
| PUBMED: | 8047140 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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