1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance Journal Article

  


Authors: Kolesnikov, Y. A.; Maccechini, M. L.; Pasternak, G. W.
Article Title: 1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance
Abstract: 1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site of the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 opioid U50,488H or the kappa3 ligand naloxone benzoylhydrazone (NalBzH). The actions of ACPC are restricted to tolerance. When given alone, ACPC has no analgesic actions in the tailflick assay and it does not change morphine's ED50 in naive mice. Chronic administration of ACPC alone for 5 days does not affect the sensitivity of mice to morphine. ACPC also reverses preexisting tolerance. When mice are made tolerant to morphine over 5 days and then receive ACPC along with their morphine, analgesia returns to naive levels within 3 days despite the continued administration of morphine. The actions of ACPC on opioid tolerance correspond closely with those previously described with both competitive and non-competitive NMDA antagonists. © 1994.
Keywords: controlled study; dose response; nonhuman; mouse; animal; mice; opiate; animal experiment; animalia; amino acids; morphine; drug therapy; analgesia; drug tolerance; mu opiate receptor; receptors, opioid, mu; glycine; naloxone; enkephalin[2,5 dextro penicillamine]; prevention; delta opiate receptor; receptors, opioid, delta; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; naloxone benzoylhydrazone; nmda receptor; enkephalin; kappa opiate receptor; subcutaneous drug administration; male; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; enkephalins; enkephalin, d-penicillamine (2,5)-; intrathecal drug administration; u50; 488h; 1 aminocyclopropanecarboxylic acid
Journal Title: Life Sciences
Volume: 55
Issue: 18
ISSN: 0024-3205
Publisher: Elsevier Inc.  
Date Published: 1994-01-01
Start Page: 1393
End Page: 1398
Language: English
DOI: 10.1016/0024-3205(94)00753-5
PROVIDER: scopus
PUBMED: 7934650
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027980235&doi=10.1016%2f0024-3205%2894%2900753-5&partnerID=40&md5=280089c88a2858f308f213721500fce8
Notes: Export Date: 14 January 2019 -- Article -- CODEN: LIFSA C2 -- Source: Scopus
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MSK Authors
  1. Yuri Alexei Kolesnikov
    34 Kolesnikov
  2. Gavril W Pasternak
    414 Pasternak
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