Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer Journal Article
| Authors: | Pisters, K. M. W.; Kris, M. G.; Gralla, R. J.; Hilaris, B.; McCormack, P. M.; Bains, M. S.; Martini, N. |
| Article Title: | Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer |
| Abstract: | This prospective randomized trial was performed to determine whether postoperative chemotherapy with vindesine and cisplatin could lengthen time to progression and overall survival in stage III (T1‐3N2MO) non‐small cell lung cancer (NSCLC) patients. Seventy‐two patients were entered; 36 were randomized to receive chemotherapy. Patients were stratified by extent of resection (complete vs. incomplete) and histology (squamous vs. nonsquamous). All had surgery and mediastinal irradiation 6–7 weeks post‐thoracotomy. Incompletely resected patients had intraoperative 125I and/or 192Ir implantation. Vindesine (3 mg/m2) weekly × 5, then every 2 weeks × 8, and cisplatin (120 mg/m2) days 1, 29, 71, 113 were planned for those randomized to chemotherapy. No difference in time to progression (median 9.2 months for radiation + chemotherapy vs. 9.0 months for radiation, P = 0.35) or overall survival (16.3 months for radiation + chemotherapy vs. 19.1 months for radiation, P = 0.42) was found. Postoperative vindesine and cisplatin did not prolong time to progression or survival in this population of stage III NSCLC. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; major clinical study; clinical trial; cancer recurrence; cisplatin; cancer growth; cancer adjuvant therapy; cancer radiotherapy; postoperative care; chemotherapy, adjuvant; combined modality therapy; neoplasm staging; controlled clinical trial; sensory neuropathy; radiation; esophagitis; leukopenia; lung non small cell cancer; nausea; randomized controlled trial; thrombocytopenia; vomiting; antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; histology; iodine 125; adjuvant chemotherapy; vindesine; alopecia; iridium 192; radiation dermatitis; intravenous drug administration; ototoxicity; humans; human; male; female; priority journal; article; non‐small cell lung cancer; postoperative therapy |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 56 |
| Issue: | 4 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1994-08-01 |
| Start Page: | 236 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1002/jso.2930560407 |
| PROVIDER: | scopus |
| PUBMED: | 8057649 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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