Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer Journal Article


Authors: Pisters, K. M. W.; Kris, M. G.; Gralla, R. J.; Hilaris, B.; McCormack, P. M.; Bains, M. S.; Martini, N.
Article Title: Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer
Abstract: This prospective randomized trial was performed to determine whether postoperative chemotherapy with vindesine and cisplatin could lengthen time to progression and overall survival in stage III (T1‐3N2MO) non‐small cell lung cancer (NSCLC) patients. Seventy‐two patients were entered; 36 were randomized to receive chemotherapy. Patients were stratified by extent of resection (complete vs. incomplete) and histology (squamous vs. nonsquamous). All had surgery and mediastinal irradiation 6–7 weeks post‐thoracotomy. Incompletely resected patients had intraoperative 125I and/or 192Ir implantation. Vindesine (3 mg/m2) weekly × 5, then every 2 weeks × 8, and cisplatin (120 mg/m2) days 1, 29, 71, 113 were planned for those randomized to chemotherapy. No difference in time to progression (median 9.2 months for radiation + chemotherapy vs. 9.0 months for radiation, P = 0.35) or overall survival (16.3 months for radiation + chemotherapy vs. 19.1 months for radiation, P = 0.42) was found. Postoperative vindesine and cisplatin did not prolong time to progression or survival in this population of stage III NSCLC. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
Keywords: adult; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; major clinical study; clinical trial; cancer recurrence; cisplatin; cancer growth; cancer adjuvant therapy; cancer radiotherapy; postoperative care; chemotherapy, adjuvant; combined modality therapy; neoplasm staging; controlled clinical trial; sensory neuropathy; radiation; esophagitis; leukopenia; lung non small cell cancer; nausea; randomized controlled trial; thrombocytopenia; vomiting; antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; histology; iodine 125; adjuvant chemotherapy; vindesine; alopecia; iridium 192; radiation dermatitis; intravenous drug administration; ototoxicity; humans; human; male; female; priority journal; article; non‐small cell lung cancer; postoperative therapy
Journal Title: Journal of Surgical Oncology
Volume: 56
Issue: 4
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 1994-08-01
Start Page: 236
End Page: 241
Language: English
DOI: 10.1002/jso.2930560407
PROVIDER: scopus
PUBMED: 8057649
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. Manjit S Bains
    338 Bains
  2. Mark Kris
    869 Kris
  3. Nael   Martini
    105 Martini
  4. Katherine M. W. Pisters
    27 Pisters
  5. Richard J. Gralla
    69 Gralla
  6. Basil B Hilaris
    43 Hilaris