Stage 4 neuroblastoma diagnosed at more than 1 year of age: Gross total resection and clinical outcome Conference Paper
| Authors: | La Quaglia, M. P.; Kushner, B. H.; Heller, G.; Bonilla, M. A.; Lindsley, K. L.; Cheung, N. K. V. |
| Title: | Stage 4 neuroblastoma diagnosed at more than 1 year of age: Gross total resection and clinical outcome |
| Conference Title: | 1993 Annual Meeting of the Section on Surgery of the American Academy of Pediatrics |
| Abstract: | The importance of gross total resection of the primary tumor in stage 4 neuroblastoma is controversial. The purpose of this study was to assess the impact of gross total resection of the primary tumor on clinical outcome in patients with stage 4 neuroblastoma diagnosed at more than 1 year of age. The authors retrospectively analyzed 70 newly diagnosed cases treated with one of five regimens of increasing dose-intensity. Outcome variables included survival time from diagnosis, and time to local recurrence or local tumor progression. Patient variables analyzed for impact on survival included age, anatomic location of the primary tumor, radiation treatment of the primary site, complete resection at diagnosis, gross total resection (GTR) at any time in the course of therapy, and treatment protocol dose-intensity. GTR was accomplished in seven patients at the time of diagnosis and in 32 patients after chemotherapy. The likelihood of complete gross resection after chemotherapy increased with greater protocol intensity. The only patient variables that correlated with improved survival were GTR (P = .03) and chemotherapy protocol (P = .01). GTR was also associated with improved local control. Although an indepedent effect of GTR on survival was not demonstrable because complete resection after chemotherapy correlated strongly with increasing protocol intensity, its association with improved overall survival was striking. These results support a continued role for GTR in high-risk neuroblastoma, along with intensive chemotherapy. © 1994. |
| Keywords: | adolescent; cancer chemotherapy; child; treatment outcome; child, preschool; survival rate; retrospective studies; major clinical study; cisplatin; conference paper; cancer radiotherapy; cancer staging; neoplasm recurrence, local; etoposide; cyclophosphamide; age factors; nephrectomy; age; survival time; infant; neuroblastoma; tumor recurrence; tumor growth; postoperative hemorrhage; small intestine obstruction; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; bladder perforation |
| Journal Title | Journal of Pediatric Surgery |
| Volume: | 29 |
| Issue: | 8 |
| Conference Dates: | 1993 Oct 29-31 |
| Conference Location: | Washington, DC |
| ISBN: | 0022-3468 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 1994-08-01 |
| Start Page: | 1162 |
| End Page: | 1166 |
| Language: | English |
| DOI: | 10.1016/0022-3468(94)90301-8 |
| PROVIDER: | scopus |
| PUBMED: | 7965527 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: JPDSA C2 -- Source: Scopus |
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