Phase II trial of liposomal encapsulated doxorubicin in patients with advanced renal cell carcinoma Journal Article
| Authors: | Murray Law, T.; Mencel, P.; Motzer, R. J. |
| Article Title: | Phase II trial of liposomal encapsulated doxorubicin in patients with advanced renal cell carcinoma |
| Abstract: | Fourteen patients with advanced renal cell carcinoma were treated on a phase II trial with liposomal encapsulated doxorubicin (Lipodox, LED). None of the fourteen evaluable patients achieved a complete or partial response. Myelosuppression was the most common toxicity and no cardiac toxicity was evident. Seventynine percent (11 of 14) of patients experienced grade III or IV neutropenia. In summary, LED did not show antitumor activity in the treatment of advanced renal cell carcinoma. © 1994 Kluwer Academic Publishers. |
| Keywords: | adult; clinical article; aged; clinical trial; neutropenia; doxorubicin; advanced cancer; phase 2 clinical trial; bone marrow suppression; antineoplastic activity; renal cell carcinoma; kidney carcinoma; kidney neoplasms; carcinoma, renal cell; cardiotoxicity; granulocyte colony stimulating factor; liposome; liposomes; intravenous drug administration; drug carriers; middle age; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; liposomal encapsulated doxorubicin |
| Journal Title: | Investigational New Drugs |
| Volume: | 12 |
| Issue: | 4 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 1994-12-01 |
| Start Page: | 323 |
| End Page: | 325 |
| Language: | English |
| DOI: | 10.1007/bf00873048 |
| PROVIDER: | scopus |
| PUBMED: | 7775134 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
