ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix Journal Article
| Authors: | Mitra, A. B.; Murty, V. V. V. S.; Pratap, M.; Sodhani, P.; Chaganti, R. S. K. |
| Article Title: | ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix |
| Abstract: | We evaluated a panel of 22 protooncogenes for amplification in 50 primary, untreated squamous cell carcinomas of the uterine cervix. The tumors studied belonged to clinical stages II and III; histologically, the majority of them were moderately to well differentiated. Amplification represented by 5 or more copies was observed for the genes MYCL1, SEAt CCND1, BCL1, and GLI in one case each (2%); HRAS in 2 cases (4%); and ERBB2 in 7 cases (14%). Amplification of ERBB2 ranged from 5 to 68 copies. In addition, 2 tumors with ERBB2 amplification showed additional restriction fragments suggesting possible mutation or rearrangement of the gene. The high incidence of ERBB2 amplification in cervical cancer suggests that this gene may play an important role in tumorigenesis. © 1994, American Association for Cancer Research. All rights reserved. |
| Keywords: | controlled study; human tissue; gene mutation; proto-oncogene proteins; carcinoma, squamous cell; cancer staging; neoplasm staging; proto oncogene; gene amplification; cell differentiation; receptor, epidermal growth factor; carcinogenesis; oncogene; gene rearrangement; dna, neoplasm; receptor, erbb-2; uterine cervix carcinoma; proto-oncogenes; cervix neoplasms; human; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Research |
| Volume: | 54 |
| Issue: | 3 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1994-02-01 |
| Start Page: | 637 |
| End Page: | 639 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 7905784 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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