The role of pelvic lymphadenectomy and radical cystectomy for lymph node positive bladder cancer: The Memorial Sloan‐Kettering Cancer Center experience Journal Article

  

Authors:	Vieweg, J.; Whitmore, W. F. Jr; Herr, H. W.; Sogani, P. C.; Russo, P.; Sheinfeld, J.; Fair, W. R.
Article Title:	The role of pelvic lymphadenectomy and radical cystectomy for lymph node positive bladder cancer: The Memorial Sloan‐Kettering Cancer Center experience
Abstract:	Background. The impact of pelvic lymph node dissection (PLND) on the survival of patients with lymph node positive bladder cancer is controversial. Methods. The authors retrospectively analyzed the long term and disease free survival among 140 patients with lymph node positive disease having radical cystectomy and bilateral PLND at the Memorial Sloan‐Kettering Cancer Center between 1980 and 1988. They also sought to identify prognostic variables for recurrence and survival. Results. Of the 140 patients, 36 (25.7%) were found to be tumor free, with 22 (15.7%) followed longer than 5 years. Regression analysis identified P‐category as the only prognostic parameter influencing survival. Patients with tumors confined to the bladder (≤P3a) had a 52.6% 5‐year survival rate compared with 23.4% among those with extravesical (≤P3b) tumors. N‐category was a significant predictor for recurrence but not survival. Conclusions. As judged from this analysis, radical cystectomy and a systematic PLND alone can provide favorable outcome in some patients with regional nodal metastases from bladder cancer. The survival advantage is most pronounced in patients with low stage primary tumors. Stage migration and patient selection may have biased these findings. Cancer 1994; 73:3020–8. Copyright © 1994 American Cancer Society
Keywords:	adult; cancer chemotherapy; cancer survival; aged; survival rate; major clinical study; cancer recurrence; cancer radiotherapy; combined modality therapy; lymph node metastasis; cancer incidence; lymph nodes; pelvis; lymph node excision; pelvis lymphadenectomy; retrospective study; bladder cancer; cystectomy; bladder neoplasms; regression analysis; bladder; nodal metastasis; prognosis; human; male; female; priority journal; article; selection factors
Journal Title:	Cancer
Volume:	73
Issue:	12
ISSN:	0008-543X
Publisher:	Wiley Blackwell
Date Published:	1994-06-15
Start Page:	3020
End Page:	3028
Language:	English
DOI:	10.1002/1097-0142(19940615)73:12<3020::Aid-cncr2820731221>3.0.Co;2-y
PROVIDER:	scopus
PUBMED:	8199999
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028356861&doi=10.1002%2f1097-0142%2819940615%2973%3a12%3c3020%3a%3aAID-CNCR2820731221%3e3.0.CO%3b2-Y&partnerID=40&md5=8f4c337af9700ed66c4d13d7f74d8867
Notes:	Export Date: 14 January 2019 -- Article -- Source: Scopus

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