μ and δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla Journal Article
| Authors: | Rossi, G. C.; Pasternak, G. W.; Bodnar, R. J. |
| Article Title: | μ and δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla |
| Abstract: | Microinjection of [d-Ala2, MePhe4, Gly(ol)5]enkephalin (DAMGO) into either the periaqueductal gray (PAG) or the rostral ventral medulla (RVM) elicts analgesia in the tailflick assay in the rat. Co-administration of DAMGO into both regions together results in a profound synergistic interaction similar to that we previously reported with morphine. U50,488H and DPDPE are inactive when given into either region. [d-Ala2, Glu4]Deltorphin (deltorphin), on the other hand, elicits an analgesic response, although the maximal response is less than than μ agonists. Co-administration of DAMGO into one region with deltorphin in the other also results in a significant synergy. However, co-administration of DAMGO and deltorphin together in the same region gives only additive effects. These results confirm the existence of μ/μ synergy between the PAG and RVM. κ1 and δ1 agents are inactive, but the δ2 agonist deltorphin is active in both regions. Our results indicate the presence of μ/δ2 synergy between the PAG and RVM which appears to involve interactions of pathways rather than receptori nteractions at the cellular level. © 1994. |
| Keywords: | controlled study; nonhuman; animal; pain; animal experiment; drug synergism; amino acid sequence; molecular sequence data; rat; rats; rats, sprague-dawley; analgesics; oligopeptides; analgesia; mu opiate receptor; receptors, opioid, mu; nociception; tail flick test; intravenous drug administration; enkephalin[2,5 dextro penicillamine]; naltrindole; pyrrolidines; delta opiate receptor; deltorphin; enkephalin, ala(2)-mephe(4)-gly(5)-; receptors, opioid, delta; synergy; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; naloxonazine; enkephalin[2 dextro alanine 4 methylphenylalanine 5 glycine]; medulla oblongata; periaqueductal gray matter; periaqueductal gray; opiate agonist; μ receptor; male; priority journal; article; enkephalin derivative; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; enkephalins; 3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-isomer; enkephalin, d-penicillamine (2,5)-; δ receptor; intracerebral drug administration |
| Journal Title: | Brain Research |
| Volume: | 665 |
| Issue: | 1 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1994-11-28 |
| Start Page: | 85 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1016/0006-8993(94)91155-x |
| PROVIDER: | scopus |
| PUBMED: | 7882023 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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