Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant Journal Article
| Authors: | Boulad, F.; Gillio, A.; Small, T. N.; Bonilla, M. A.; Philips, P.; Ruggiero, M.; Emanuel, D.; Ghavimi, F.; Kernan, N. A. |
| Article Title: | Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant |
| Abstract: | We describe a patient who presented with graft failure following autologous BMT, with an initial response of the neutrophil count to rHuGM-CSF but eventual loss of this response. Subsequently, this patient responded to rHuG-CSF. This could be explained by the fact that rHuG-CSF stimulates both early and late myeloid progenitor cells whereas rHuGM-CSF stimulates mainly the intermediate myeloid progenitor cells. This finding suggests that rHuG-CSF should be investigated for the treatment of patients with graft failure following ABMT. |
| Keywords: | adolescent; neutropenia; case report; cisplatin; etoposide; granulocyte macrophage colony stimulating factor; melphalan; drug effect; graft failure; neutrophil; recombinant proteins; leukocyte count; recombinant granulocyte colony stimulating factor; cell stimulation; bone marrow transplantation; granulocyte colony-stimulating factor; transplantation, autologous; intravenous drug administration; autologous bone marrow transplantation; promyelocyte; granulocyte-macrophage colony-stimulating factor; infectious pneumonia; amphotericin b; subcutaneous drug administration; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1994-05-01 |
| Start Page: | 661 |
| End Page: | 663 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 7519939 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
