Synthesis and in vitro cytotoxicity of 6-vinyluridine and related compounds Journal Article
| Authors: | Megati, S.; Sodum, R.; Otter, G. M.; Klein, R. S.; Otter, B. A. |
| Article Title: | Synthesis and in vitro cytotoxicity of 6-vinyluridine and related compounds |
| Abstract: | The 6-alkenyluracil nucleosides (7a-e) and bases (14a-i) were synthesized and evaluated for their ability to inhibit the growth of mouse leukemia L1210 cells in vitro. While several of the free bases are cytotoxic, with IC50 values in the 1 - 5 μM range, the corresponding β-d-ribofuranosyl nucleosides are not significantly active. © 1994. |
| Keywords: | controlled study; unclassified drug; nonhuman; animal cell; mouse; cytotoxicity; drug structure; drug synthesis; structure activity relation; nucleoside; enantiomer; uridine derivative; article; ultraviolet spectrophotometry; leukemia l 1210; 6 vinyluracil; 6 vinyluridine |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1994-02-10 |
| Start Page: | 469 |
| End Page: | 472 |
| Language: | English |
| DOI: | 10.1016/0960-894x(94)80018-9 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
