Loss of heterozygosity and decreased expression of NME genes correlate with teratomatous differentiation in human male germ cell tumors Journal Article

  

Authors:	Backer, J. M.; Murty, V. V. V. S.; Potla, L.; Mendola, C. E.; Rodriguez, E.; Reuter, V. E.; Bosl, G. G.; Chaganti, R. S. K.
Article Title:	Loss of heterozygosity and decreased expression of NME genes correlate with teratomatous differentiation in human male germ cell tumors
Abstract:	Embryonal carcinoma in the human male is a pluripotential germ cell tumor (GCT), which is suggested to further differentiate to teratoma which displays somatic differentiation representing all three germinal layers. In a panel of 37 GCTs we determined frequency of loss of heterozygosity (LOH) and the level of expression of nucleoside diphosphate kinase (NDPK) genes NME 1 and NME 2. The frequency of LOH in teratomas (86%) was found to be highly significant (P<0.01) compared to embryonal carcinomas (17%). We also found that the NME encoded proteins are expressed at a 4-5 fold lower level in teratomas compared to embryonal carcinomas. These findings lead us to hypothesize that a critical level of NDPK may be necessary for suppression of aberrant somatic differentiation. © 1994 Academic Press, Inc.
Journal Title:	Biochemical and Biophysical Research Communications
Volume:	202
Issue:	2
ISSN:	0006-291X
Publisher:	Elsevier Science, Inc.
Date Published:	1994-07-29
Start Page:	1096
End Page:	1103
Language:	English
DOI:	10.1006/bbrc.1994.2041
PROVIDER:	scopus
PUBMED:	8048923
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028088189&doi=10.1006%2fbbrc.1994.2041&partnerID=40&md5=51c5aa65d16a7b262d05ccf303dd1859
Notes:	Export Date: 14 January 2019 -- Article -- Source: Scopus

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