Angiosarcoma of the head and neck Journal Article
| Authors: | Lydiatt, W. M.; Shaha, A. R.; Shah, J. P. |
| Article Title: | Angiosarcoma of the head and neck |
| Abstract: | Background: Angiosarcoma (AS) is an uncommon, highly aggressive tumor with a poor prognosis. Methods: To study the impact of various treatment modalities, namely surgery, radiation, and chemotherapy, we reviewed our experience with AS of the head and neck. Results: From 1978 through 1992, we treated 13 men and 5 women with AS (median age 67 years). Sixteen tumors occurred on the scalp and face and 2 in the oropharynx. Two patients presented with cervical metastases, and a third had subsequent nodal involvement. Primary surgery was used in 9 patients, including 1 who received adjunctive systemic doxorubicin hydrochloride, and 2 who received adjunctive radiotherapy. The tumors of 9 patients were unresectable: 4 were treated with intra-arterial doxorubicin hydrochloride; and 5, with systemic doxorubicin hydrochloride. Twelve patients (67%) died of disease an average of 25 months after diagnosis. Overall 5-year survival was 33%, but only 20% of the patients were disease free. Size of the tumor was an important predictor of survival, as all patients with a lesion >10 cm died of disease, compared with 67% with a lesion <10 cm. Four of 6 patients treated with wide local excision for lesions <10 cm survived 5 years. Conclusions: We recommend surgery for resectable lesions with postoperative radiation for unsatisfactory margins, large tumor size, deep extension, and multicentricity. Elective treatment of the neck does not appear warranted. © 1994. |
| Keywords: | adult; cancer survival; clinical article; aged; cancer surgery; survival rate; retrospective studies; cancer localization; doxorubicin; conference paper; cancer radiotherapy; combined modality therapy; tumor volume; angiosarcoma; hemangiosarcoma; head and neck cancer; head and neck neoplasms; human; male; female; priority journal |
| Journal Title: | American Journal of Surgery |
| Volume: | 168 |
| Issue: | 5 |
| ISSN: | 0002-9610 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-11-01 |
| Start Page: | 451 |
| End Page: | 454 |
| Language: | English |
| DOI: | 10.1016/s0002-9610(05)80097-2 |
| PROVIDER: | scopus |
| PUBMED: | 7977971 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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