Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them Journal Article


Authors: Sorbara, M. T.; Pamer, E. G.
Article Title: Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them
Abstract: The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competition with related and unrelated strains. Importantly, these normal activities contribute to colonization resistance by the healthy microbiota, which includes the ability to prevent the expansion of potential pathogens. Disruption of the microbiota, resulting from, for example, inflammation or antibiotic use, can reduce colonization resistance. Pathogens that engraft following disruption of the microbiota are often adapted to expand into newly created niches and compete in an altered gut environment. In this review, we examine both the interbacterial mechanisms of colonization resistance and the strategies of pathogenic strains to exploit gaps in colonization resistance. © 2018, Society for Mucosal Immunology.
Journal Title: Mucosal Immunology
Volume: 12
Issue: 1
ISSN: 1933-0219
Publisher: Nature Publishing Group  
Date Published: 2019-01-01
Start Page: 1
End Page: 9
Language: English
DOI: 10.1038/s41385-018-0053-0
PROVIDER: scopus c2 - 29988120
PMCID: PMC6312114
PUBMED: 29988120
DOI/URL:
Notes: Mucosal Immunol. -- Cited By :1 -- Export Date: 2 January 2019 -- Review -- Source: Scopus C2 - 29988120
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MSK Authors
  1. Eric Pamer
    237 Pamer