Granular cell tumor of the bladder: A report of six cases Journal Article


Authors: Sun, Y.; Reuter, V. E.; Magi-Galluzzi, C.; Sankin, A.; Epstein, J. I.
Article Title: Granular cell tumor of the bladder: A report of six cases
Abstract: Objective: To better characterize granular cell tumor of the bladder, with only 20 cases reported to date and unclear management guidelines. Methods: We report five benign and one malignant granular cell tumor of the bladder. Results: Patients were in the age range of 33 to 73 years. The size of tumor ranged from 0.2 to 6.3 cm. Two benign granular cell tumors were incidental findings with others presenting with painless hematuria. Benign granular cell tumors infiltrated the muscularis propria and were confirmed by immunohistochemistry for S100 protein with negative stains for keratins. The malignant granular cell tumor involved the entire bladder wall with extension into perivesical tissue. Benign granular cell tumors were treated by transurethral resection (TUR) or partial cystectomy; all patients were disease free at last follow-up. The malignant granular cell tumor was treated by anterior exenteration and bilateral pelvic lymphadenectomy. This patient developed pulmonary and pleural metastases 2 years after surgery. Conclusion: Given the locally infiltrative nature of granular cell tumors and that 50% of reported benign granular cell tumors with sufficient follow-up recurred following initial TUR, it is prudent to recommend partial cystectomy if technically feasible. A later TUR at a time of tumor regrowth could result in obstruction of ureters depending on their location and with greater infiltrative growth, with larger subsequent resections be needed for complete removal. In other cases, immediate repeat TUR after a diagnosis of granular cell tumor would lessen the likelihood of local recurrence. Either partial or radical cystectomy is needed for the rare malignant granular cell tumor. © 2018 Elsevier Inc.
Keywords: immunohistochemistry; adult; clinical article; aged; middle aged; cancer surgery; case report; tumor volume; pelvis lymphadenectomy; bladder cancer; hematuria; lung metastasis; cancer infiltration; cystectomy; protein s 100; incidental finding; transurethral resection; pleura metastasis; keratin; granular cell tumor; human; male; female; priority journal; article
Journal Title: Urology
Volume: 121
ISSN: 0090-4295
Publisher: Elsevier Science, Inc.  
Date Published: 2018-11-01
Start Page: 203.e1
End Page: 203.e5
Language: English
DOI: 10.1016/j.urology.2018.08.018
PROVIDER: scopus
PUBMED: 30170086
DOI/URL:
Notes: Urology -- Export Date: 2 January 2019 -- Article -- CODEN: URGYA C2 - 30170086 -- Source: Scopus
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MSK Authors
  1. Victor Reuter
    922 Reuter