Long-term quality of life in older patients with HPV-related oropharyngeal cancer Journal Article


Authors: Baxi, S. S.; Cullen, G.; Xiao, H.; Atoria, C. L.; Sherman, E. J.; Ho, A.; Lee, N. Y.; Elkin, E. B.; Pfister, D. G.
Article Title: Long-term quality of life in older patients with HPV-related oropharyngeal cancer
Abstract: Background: We explored if age affects quality of life (QOL) in survivors of locally advanced human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC). Methods: In a cross-sectional survey of 185 patients, at least 12 months from radiation, we evaluated generic (EuroQOL-5D questionnaire [EQ-5D]) and head and neck specific (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35-questions [EORTC-QLQ-H&N35]) QOL questionnaires and compared differences between younger (<65) and older (≥65) patients. Results: The median age was 57.0 years (range 25-77 years), and 31 patients (16.8%) were ≥65 years old. There was no significant difference in EQ-5D global QOL scores by age (P =.53). Patients ≥65 years reported more immobility (P <.01), problems with social eating (P <.0001), and coughing (P <.01). Patients ≥65 years were not more likely to ever require a gastrostomy (P =.24) but were more likely to remain gastrostomy-dependent at the time of the survey (P =.02). Conclusion: Despite similar generic QOL, older survivors may have more mobility problems and issues with social eating compared with younger survivors deserving of further evaluation. © 2018 Wiley Periodicals, Inc.
Keywords: quality of life; geriatrics; human papillomavirus; oropharyngeal cancer
Journal Title: Head & Neck
Volume: 40
Issue: 11
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2018-11-01
Start Page: 2321
End Page: 2328
Language: English
DOI: 10.1002/hed.25159
PROVIDER: scopus
PUBMED: 30421835
PMCID: PMC6681446
DOI/URL:
Notes: Head Neck -- Export Date: 2 January 2019 -- Article -- CODEN: HEANE C2 - 30421835 -- Source: Scopus
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MSK Authors
  1. Han Xiao
    61 Xiao
  2. Eric J Sherman
    346 Sherman
  3. Elena B Elkin
    163 Elkin
  4. Nancy Y. Lee
    889 Lee
  5. David G Pfister
    389 Pfister
  6. Shrujal S Baxi
    107 Baxi
  7. Alan Loh Ho
    242 Ho
  8. Coral Lynn Atoria
    51 Atoria
  9. Grace Dalton Cullen
    5 Cullen