Systemic mastocytosis, version 2.2019: Clinical Practice Guidelines in Oncology Journal Article


Authors: Gotlib, J.; Gerds, A. T.; Bose, P.; Castells, M. C.; Deininger, M. W.; Gojo, I.; Gundabolu, K.; Hobbs, G.; Jamieson, C.; McMahon, B.; Mohan, S. R.; Oehler, V.; Oh, S.; Padron, E.; Pancari, P.; Papadantonakis, N.; Pardanani, A.; Podoltsev, N.; Rampal, R.; Ranheim, E.; Rein, L.; Snyder, D. S.; Stein, B. L.; Talpaz, M.; Thota, S.; Wadleigh, M.; Walsh, K.; Bergman, M. A.; Sundar, H.
Article Title: Systemic mastocytosis, version 2.2019: Clinical Practice Guidelines in Oncology
Abstract: Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocytosis diagnosed in adults, characterized by mast cell infiltration of one or more extracutaneous organs (with or without skin involvement). The identification of KIT D816V mutation and the emergence of novel targeted therapies have significantly improved the diagnosis and treatment of systemic mastocytosis. However, certain aspects of clinical care, particularly the diagnosis, assessment, and management of mediator-related symptoms continue to present challenges. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with systemic mastocytosis. © National Comprehensive Cancer Network, Inc. 2018, All rights reserved.
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 16
Issue: 12
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2018-12-01
Start Page: 1500
End Page: 1537
Language: English
DOI: 10.6004/jnccn.2018.0088
PROVIDER: scopus c2 - 30545997
DOI/URL:
Notes: JNCCN J. Nat. Compr. Cancer Netw. -- Export Date: 2 January 2019 -- Article -- Source: Scopus C2 - 30545997
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  1. Raajit Kumar Rampal
    125 Rampal