Management of biochemically recurrent prostate cancer: Ensuring the right treatment of the right patient at the right time Journal Article
| Authors: | Spratt, D. E.; McHugh, D. J.; Morris, M. J.; Morgans, A. K. |
| Article Title: | Management of biochemically recurrent prostate cancer: Ensuring the right treatment of the right patient at the right time |
| Abstract: | Biochemically recurrent prostate cancer is an increasingly common disease state, with more than 25,000 cases occurring annually in the United States. Fortunately, progress continues to be made to more effectively identify metastatic disease, optimize existing therapies, and develop new technologies and therapeutic strategies for the timing and delivery of systemic treatments to improve outcomes. This review covers three topics related to the diagnosis and treatment of men with biochemical recurrence (BCR). First, we provide an update on the state of the rapidly evolving field of molecular imaging and its place in practice. Second, we describe validated clinicopathologic methods to risk stratify patients with biochemically recurrent disease, including new gene expression classifiers, to personalize postoperative radiotherapy (RT) timing. Last, we define our approach to optimal management with systemic therapy, including identifying the patients who may benefit most and balancing the duration and timing of treatment with consideration of the effect of therapy on quality of life (QOL) and medical complications associated with treatment. |
| Keywords: | treatment outcome; mortality; multimodality cancer therapy; patient selection; combined modality therapy; recurrence; molecular imaging; tumor marker; prostatic neoplasms; prostate tumor; recurrent disease; disease management; procedures; time to treatment; time-to-treatment; humans; human; male; biomarkers, tumor |
| Journal Title: | American Society of Clinical Oncology Educational Book |
| Volume: | 38 |
| ISSN: | 1548-8756 |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2018-05-23 |
| Start Page: | 355 |
| End Page: | 362 |
| Language: | English |
| DOI: | 10.1200/edbk_200319 |
| PROVIDER: | scopus |
| PUBMED: | 30231323 |
| DOI/URL: | |
| Notes: | Am Soc Clin Oncol Educ Book -- Export Date: 2 January 2019 -- Review -- Source: Scopus C2 - 30231323 |
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