Interpretable spiculation quantification for lung cancer screening Conference Paper
| Authors: | Choi, W.; Nadeem, S.; Riyahi, S.; Deasy, J. O.; Tannenbaum, A.; Lu, W. |
| Title: | Interpretable spiculation quantification for lung cancer screening |
| Conference Title: | International Workshop on Shape in Medical Imaging (ShapeMI 2018) |
| Abstract: | Spiculations are spikes on the surface of pulmonary nodule and are important predictors of malignancy in lung cancer. In this work, we introduced an interpretable, parameter-free technique for quantifying this critical feature using the area distortion metric from the spherical conformal (angle-preserving) parameterization. The conformal factor in the spherical mapping formulation provides a direct measure of spiculation which can be used to detect spikes and compute spike heights for geometrically-complex spiculations. The use of the area distortion metric from conformal mapping has never been exploited before in this context. Based on the area distortion metric and the spiculation height, we introduced a novel spiculation score. A combination of our spiculation measures was found to be highly correlated (Spearman’s rank correlation coefficient with the radiologist’s spiculation score. These measures were also used in the radiomics framework to achieve state-of-the-art malignancy prediction accuracy of 88.9% on a publicly available dataset. © 2018, Springer Nature Switzerland AG. |
| Keywords: | medical imaging; diagnosis; pulmonary nodules; biological organs; diseases; lung cancer screening; conformal mapping; critical features; conformal factors; distortion metrics; prediction accuracy; rank correlation coefficient; spiculation scores |
| Journal Title | Lecture Notes in Computer Science |
| Volume: | 11167 |
| Conference Dates: | 2018 Sep 20 |
| Conference Location: | Granada, Spain |
| ISBN: | 0302-9743 |
| Publisher: | Springer |
| Date Published: | 2018-01-01 |
| Start Page: | 38 |
| End Page: | 48 |
| Language: | English |
| DOI: | 10.1007/978-3-030-04747-4_4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Part of "Shape in Medical Imaging" (ISBN: 978-3-030-04746-7) -- Export Date: 2 January 2019 -- Conference Paper -- Source: Scopus |
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70Lu -
21Choi -
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Riyahi Alam -
50Nadeem
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