Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings? Journal Article
| Authors: | Rudomina, D. E.; Lin, O.; Moreira, A. L. |
| Article Title: | Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings? |
| Abstract: | Micropapillary adenocarcinoma is associated with poor-prognosis in several organs including the lung. The presence of small tight balls of neoplastic cells devoid of fibrovascular core in cytological preparations (micropapillary tufts) has been described as characteristic of micropapillary adenocarcinoma. In the lung, however, this criterion has not been validated. The cytological material of 46 cases of histologically proven pulmonary adenocarcinoma with a micropapillary component was compared to 33 cases with no micropapillary component to determine the specificity of micropapillary tufts for the histologic diagnosis of micropapillary adenocarcinoma. Other histologic patterns of invasive pulmonary adenocarcinomas (acinar, papillary, and solid) were also compared with patterns of neoplastic cell aggregates in cytological preparations. There were no significant differences in the distribution of micropapillary clusters between the two groups. The positive predictive value for the cytologic diagnosis of a micropapillary component in lung adenocarcinomas was of 64%. Similar findings were observed for other invasive patterns. Therefore, the detection of micropapillary tufts in cytology is not specific for the diagnosis of a pulmonary micropapillary adenocarcinoma in the lung. © 2009 Wiley-Liss, Inc. |
| Keywords: | adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; cancer surgery; human cell; major clinical study; cancer diagnosis; adenocarcinoma; cytology; cell maturation; lung resection; lung neoplasms; cell motion; histology; tissue section; correlation analysis; lung adenocarcinoma; statistical significance; tumor cell; lung; prediction and forecasting; cell aggregation; cell nucleus; papillary carcinoma; aspiration biopsy; cytodiagnosis; cell membrane permeability; micropapillary carcinoma; cell degeneration |
| Journal Title: | Diagnostic Cytopathology |
| Volume: | 37 |
| Issue: | 5 |
| ISSN: | 8755-1039 |
| Publisher: | Wiley Liss |
| Date Published: | 2009-05-01 |
| Start Page: | 333 |
| End Page: | 339 |
| Language: | English |
| DOI: | 10.1002/dc.21011 |
| PUBMED: | 19191297 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: DICYE" - "Source: Scopus" |
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