Biomarker-driven and molecular targeted therapies for hepatobiliary cancers Journal Article
| Authors: | Harris, W. P.; Wong, K. M.; Saha, S.; El Dika, I.; Abou-Alfa, G. K. |
| Article Title: | Biomarker-driven and molecular targeted therapies for hepatobiliary cancers |
| Abstract: | The recent accumulation of molecular profiling data for primary hepatobiliary malignancies, including hepatocellular carcinoma and biliary tract cancers, has led to a proliferation of promising therapeutic investigations in recent years. Treatment with pathway-specific targeted inhibitors and immunotherapeutic agents have demonstrated promising early clinical results. Key molecular alterations in common hepatobiliary cancers and ongoing interventional clinical trials of molecularly targeted systemic agents focusing on hepatocellular carcinoma and biliary tract cancer are reviewed. © 2018 Elsevier Inc. |
| Keywords: | hepatocellular carcinoma; systemic therapy; immunotherapy; liver cancer; intrahepatic cholangiocarcinoma; cholangiocarcinoma; biliary tract cancer; clinical trials; molecular therapy; hcc; icc; hepatobiliary; immuno-oncology; targeted therapeutics |
| Journal Title: | Seminars in Oncology |
| Volume: | 45 |
| Issue: | 3 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-06-01 |
| Start Page: | 116 |
| End Page: | 123 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2018.03.002 |
| PUBMED: | 30348531 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 December 2018 -- Source: Scopus |
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