Imaging and the completion of the omics paradigm in breast cancer Journal Article


Authors: Leithner, D.; Horvat, J. V.; Ochoa-Albiztegui, R. E.; Thakur, S.; Wengert, G.; Morris, E. A.; Helbich, T. H.; Pinker, K.
Article Title: Imaging and the completion of the omics paradigm in breast cancer
Abstract: Within the field of oncology, “omics” strategies—genomics, transcriptomics, proteomics, metabolomics—have many potential applications and may significantly improve our understanding of the underlying processes of cancer development and progression. Omics strategies aim to develop meaningful imaging biomarkers for breast cancer (BC) by rapid assessment of large datasets with different biological information. In BC the paradigm of omics technologies has always favored the integration of multiple layers of omics data to achieve a complete portrait of BC. Advances in medical imaging technologies, image analysis, and the development of high-throughput methods that can extract and correlate multiple imaging parameters with “omics” data have ushered in a new direction in medical research. Radiogenomics is a novel omics strategy that aims to correlate imaging characteristics (i. e., the imaging phenotype) with underlying gene expression patterns, gene mutations, and other genome-related characteristics. Radiogenomics not only represents the evolution in the radiology–pathology correlation from the anatomical–histological level to the molecular level, but it is also a pivotal step in the omics paradigm in BC in order to fully characterize BC. Armed with modern analytical software tools, radiogenomics leads to new discoveries of quantitative and qualitative imaging biomarkers that offer hitherto unprecedented insights into the complex tumor biology and facilitate a deeper understanding of cancer development and progression. The field of radiogenomics in breast cancer is rapidly evolving, and results from previous studies are encouraging. It can be expected that radiogenomics will play an important role in the future and has the potential to revolutionize the diagnosis, treatment, and prognosis of BC patients. This article aims to give an overview of breast radiogenomics, its current role, future applications, and challenges. © 2018, The Author(s).
Keywords: magnetic resonance imaging; biomarkers; gene expression; breast neoplasms; diffusion-weighted imaging; molecular subtypes
Journal Title: Der Radiologe
Volume: 58
Issue: Suppl. 1
ISSN: 0033-832X
Publisher: Springer  
Date Published: 2018-11-01
Start Page: 7
End Page: 13
Language: English
DOI: 10.1007/s00117-018-0409-1
PUBMED: 29947931
PROVIDER: scopus
PMCID: PMC6244523
DOI/URL:
Notes: Review -- Export Date: 3 December 2018 -- Source: Scopus
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